Rye Staging System

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Rye Staging System

A system for staging Hodgkin's disease delineated in 1966, which divided it into 4 distinct clinicopathological categories, based on data provided by the then popular method of lymphangiography. Cf Ann Arbor classification, Cotswolds classification.

Rye Classification–Hodgkin's disease

Lymphocytic predominant 10% of cases, more common in young adult ♂, usually early/low-stage disease without 'B' symptoms, 5-year survival: 90%

Nodular sclerosing 40%; more common in young adult ♀, usually early and low-stage disease with or without 'B' symptoms, 5-year survival: 70%

Mixed cellularity 40%; more common in young adult ♂, often stage II-III disease with or without 'B' symptoms, 5-year survival: 50%

Lymphocyte-depleted 10%; more common in older adult ?, usually stage III-IV disease with or without 'B' symptoms, 5-year survival, 30%

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