Group 3, (the sub- and supra-gingival plaque biofilm) showed the greatest bacterial diversity and had a further decrease in Firmicutes compared to Groups 1 and 2, with a marked increase in the relative abundance of Actinobacteria and with a similar profile of genera as Group 2 plus Corynebacterium, Capnocytophaga, Rothia
and Porphyromonas (6)
Vaccination with PCV-7 resulted in a shift in bacterial community composition and structure, with an increase in presence or abundance of several anaerobes, such as Veillonella, Prevotella, Fusobacterium, and Leptotrichia species; gram-positive bacteria, such as Actinomyces and Rothia species, and nonpneumococcal streptococci; and gram-negative Neisseria species.
pneumoniae and the presence of Veillonella, Neisseria, Rothia, and Actinomyces spp.
mucilaginosa, Streptococcus oralis, and Streptococcus mitis), or environmental flora (Bacillus thuringensis).
dentocariosa, and Propionibacterium propionicus (formerly Arachnia propionica).
Upon manual review, 12 were confirmed without changes, 2 clusters contained at least 1 isolate with >1% sequence difference in pairwise comparisons, 2 clusters were split because of >1% sequence heterogeneity, and isolates of 3 clusters could be identified to validly described species: Rothia aeria, Cardiobacterium hominis, and Streptomyces thermoviolaceus subsp.
9 5 5 Gram stain Family morphology Result Micrococcaceae GPR Rothia aeria, short reference sequence Actinomycetaceae GPR 1 strain with >1% dissimilarity Thermoactinomycetaceae GPR Belong to Kroppenstedtia eburnea gen.
Gardnerella vaginalis Clinical isolates Rothia
dentocariosa Clinical isolates Common uropathogens Alcaligenes faecalis Clinical isolates Candida albicans Clinical isolates Citrobacter koseri Clinical isolates Escherichia coli Clinical isolates Hemolytic streptococcus group A Clinical isolates Hemolytic streptococcus group B Clinical isolates Klebsiella oxytoca Clinical isolates K.