Thus, potentiation of rosetting appears specific (but not exclusive) to A and B antigens.
Not surprisingly, in vitro rosetting is more pronounced in parasite strains derived from patients with severe disease, particularly in cases of cerebral malaria.
Plasmodium falciparum values with similar superscipt alphabets do not differ significantly rosetting is associated with malaria severity in Kenya.
Plasmodium falciparum values rosetting is associated with malaria severity in Kenya.
Several mechanisms facilitate this persistence, including antigenic variation, binding of factor H, and rosetting of erythrocytes (25-27).
Burman N, Shamaei-Tousi A, Bergstrom S, The spirochete Borrelia crocidurae causes erythrocyte rosetting during relapsing fever.
The A and B trisaccharides are thought to act as receptors for rosetting on uninfected erythrocytes and direct binding between the parasite rosetting ligand PfEMP1 and the A antigen has been demonstrated.
Blood group O protects against severe Plasmodium falcipanum malaria through the mechanism of reduced rosetting.
Plasmodium falciparum rosetting is associated with malaria severity in Kenya.
The process of binding of uninfected erythrocytes to the erythrocytes infected with mature asexual parasites is called rosetting (10).
Given the important role of Knops polymorphic phenotypes of CR1 in rosetting of RBCs and the fact that this polymorphism of CR1 has not been studied till date in the Indian population, we investigated the role of CR1 Knops polymorphism in the pathophysiology of malaria in Indian population.
From the results obtained in the present study, we have concluded that only the homozygous wild type form of the Knops polymorphism is prevalent in the Indian population and that the process of rosetting in the Indian context could be occurring independently of the effect of Knops polymorphism loci of CR1.