ristocetin


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ris·to·ce·tin

(ris'tō-sē'tin),
An antibiotic produced by the fermentation of Amycolatopsis orientalis subsp. lurida, comprising two substances; ristocetin A and ristocetin B; although no longer used, it causes platelet agglutination and blood coagulation and was used to assay those functions.
Synonym(s): ristomycin

ristocetin

(rĭs″tō-sē′tĭn)
An antibiotic obtained from cultures of Nocardia lurida.

ristocetin

an antibiotic produced by cultures of the actinomycete Nocardia lurida. Used also in the assessment of platelet function.

ristocetin cofactor
inolved in platelet aggregation. Called also von Willebrand factor.
References in periodicals archive ?
Platelet aggregation is highly specific for GT, as platelet aggregation fails to occur with any agonist, except ristocetin, where the reaction is preserved.
3] Nonstandard abbreviations: FVIII, factor VIII; PT, prothrombin time; APTT, activated partial thromboplastin time; AT, antithrombin; VWF, von Willebrand factor; VWF:Ag, VWF antigen; VWF:CB, VWF collagen binding; VWF:RCo, VWF ristocetin cofactor activity; FVIII:C, FVIII coagulant activity; FIX:C, FIX coagulant activity; PC-chrom, protein C chromogenic; PS-act, protein S activity; PS-total, protein S total; PS-free, protein S free; PC-clot, PC clotting; [CV.
Historically, VWF activity was mostly measured using the antibiotic ristocetin as a cofactor, which enhances the binding of VWF to the platelet GPIb receptor (42).
In patients with BTM and HBT, reduced platelet aggregation response to epinephrine, collagen, ADP and ristocetin could be explained by a defect or an impairment in glycoprotein structure of receptors on platelet membranes.
For test-associated errors, ristocetin cofactor was associated with the highest variability and error rate, which was at least twice that using collagen binding.
Whole blood count, peripheral blood smear, blood group, ferritin, platelet function analyzer 100 (PFA-100), prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen, von Willebrand factor antigen (VWF:Ag), VWF ristocetin cofactor (VWF:RCo), factor VIII (F Viii), and platelet aggregation assays were performed.
1] To rule out coagulopathies, a structured history, Von Willebrand factor assay and ristocetin cofactor assay may be done if necessary.
For patients undergoing major surgery, the goal of therapy is to treat with DDAVP or FVIII concentrates to maintain ristocetin cofactor levels between 50-100% for a period of 3-10 days and if the patient undergoes a percutaneous procedure, the length of treatment is shorter (18).
5% concentration and aggregation done by arachidonic acid without affecting platelet aggregation induced by high dose of ADP, collagen, ristocetin, and adrenalin was defined.
In 34 patients the deficiency of vWF was later confirmed by getting ristocetin induced platelet aggregation on mixing patient plasma with control plasma.
Efficacy and safety of the factor VIII/von Willebrand factor concentrate, haemate-P/humate-P: ristocetin cofactor unit dosing in patients with von Willebrand disease.
The response to the following agonists are now routinely assessed by LTA in our laboratory: (a) ristocetin (Catalogue number 5199; 15mg/ml; Helena Laboratories, Melbourne Australia), used at two or more concentrations to assess minimum and maximum thresholds (typically over the range 0.