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ristocetin

   Also found in: Wikipedia 0.01 sec.
ristocetin
an antibiotic produced by cultures of the actinomycete Nocardia lurida. Used also in the assessment of platelet function.

ristocetin cofactor
inolved in platelet aggregation. Called also von Willebrand factor.


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Testing platelet response to the agonists ADP, Collagen, Epinephrine and Ristocetin showed an increased response to low concentration Ristocetin (Figure 1a) which is consistent with type 2B vWD (1).
A marked elevation in von Willebrand factor antigen (factor VIII:Ag), an elevation in ristocetin cofactor (VIII:RcoF) (Rossi et al 1980) and a slight elevation in factor VIII:C, has been observed to occur prior to the development of DVT (Myllenen et al 1987, Rossi et al 1980).
The prothrombin time, partial thromboplastin time, plasma fibrinogen concentration, von Willebrand factor antigen concentration, Factor VIII activity, and ristocetin cofactor activity were all normal.
 
 
 
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