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riluzole |
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riluzole /ril·u·zole/ (ril´u-zol) a compound used to prolong survival time in the treatment of amyotrophic lateral sclerosis. Riluzole (Rilutek) The first drug approved in the United States for the treatment of ALS. Mentioned in: Amyotrophic Lateral Sclerosis riluzole (ril´ n brand name: Rilutek; drug class: glutamate antagonist; action: inhibits presynaptic release of glutamic acid in central nervous system; use: treatment of amyotrophic lateral sclerosis (Lou Gehrig disease). riluzole Rilutek Pharmacologic class: Glutamate antagonist Therapeutic class: Amyotrophic lateral sclerosis (ALS) agent Pregnancy risk category C ActionUnknown. Thought to inhibit amino acid accumulation on motor neurons of CNS, improving nerve impulse transmission. AvailabilityTablets: 50 mg ⊘Indications and dosages ➣ ALS Adults: 50 mg P.O. q 12 hours Off-label uses• Cervical dystonia Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Give at least 1 hour before or 2 hours after a meal to maximize absorption.
Adverse reactionsCNS: headache, dizziness, drowsiness, asthenia, hypertonia, depression, insomnia, malaise, vertigo, circumoral paresthesia CV: hypertension, orthostatic hypotension, tachycardia, palpitations, peripheral edema, phlebitis, cardiac arrest EENT: rhinitis, sinusitis, oral candidiasis GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, flatulence, stomatitis, dry mouth, anorexia GU: urinary tract infection, dysuria Hematologic: neutropenia Musculoskeletal: back pain, joint pain Respiratory: decreased lung function, increased cough, pneumonia Skin: pruritus, eczema, alopecia, exfoliative dermatitis Other: tooth disorders, weight loss InteractionsDrug-drug. Allopurinol, methyldopa, sulfasalazine: increased risk of hepatotoxicity CYP450-1A2 inducers (such as omeprazole, rifampin): increased riluzole elimination CYP450-1A2 inhibitors (such as amitriptyline, phenacetin, quinolones, theophylline): decreased riluzole elimination Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, bilirubin, gamma-glutamyltransferase: increased levels Drug-food. High-fat foods: decreased riluzole absorption Drug-behaviors. Alcohol use: increased risk of hepatotoxicity Patient monitoring• Monitor liver function tests and CBC. Patient teaching• Tell patient to take 1 hour before or 2 hours after a meal, at same time each day. |
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