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rifapentine |
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rifapentine /rif·a·pen·tine/ (-pen´tēn) a synthetic rifamycin antibiotic used in the treatment of pulmonary tuberculosis. rifapentine, an antitubercular. indications Rifapentine is used to treat pulmonary tuberculosis. It must be used in combination with at least one other antitubercular. contraindication Known hypersensitivity to rifamycin prohibits its use. adverse effects Life-threatening effects include pancreatitis, hematuria, proteinuria, thrombocytopenia, leukopenia, neutropenia, lymphopenia, and leukocytosis. Other adverse effects include rash, pruritus, urticaria, acne, visual disturbances, gout, arthrosis, edema, aggressive reaction, bilirubinemia, hepatitis, increased AST/ALT, pyuria, urinary casts, headache, fatigue, anxiety, dizziness, anemia, purpura, and hematoma. Common side effects include nausea, vomiting, anorexia, diarrhea, and heartburn. rifapentine Priftin Pharmacologic class: Rifamycin derivative Therapeutic class: Antitubercular Pregnancy risk category C ActionInhibits RNA synthesis by blocking RNA transcription in susceptible organisms (mycobacteria and some gram-positive and gram-negative bacteria) AvailabilityTablets: 150 mg ⊘Indications and dosages ➣ Pulmonary tuberculosis (TB) Adults: Intensive-phase treatment - 600 mg P.O. twice weekly for 2 months, with doses spaced 72 hours apart; must be given with at least one other antitubercular. Continuation-phase treatment - 600 mg P.O. once weekly for 4 months, given with another antitubercular. Off-label uses• Mycobacterium avium intracellulare complex infection Contraindications• Hypersensitivity to drug or other rifamycin derivatives PrecautionsUse cautiously in: Administration• Know that drug is given with at least one other antitubercular.
Adverse reactionsCNS: headache, fatigue, anxiety, dizziness, aggressive behavior CV: hypertension, peripheral edema EENT: visual disturbances; discolored tears, sputum, and saliva GI: nausea, vomiting, diarrhea, dyspepsia, esophagitis, gastritis, discolored feces, anorexia, pancreatitis GU: hematuria, pyuria, proteinuria, urinary casts, discolored urine Hematologic: anemia, thrombocytosis, hematoma, purpura, eosinophilia, neutropenia, leukopenia Hepatic: hepatitis Metabolic: hyperuricemia, hypovolemia, hyperkalemia Musculoskeletal: gout, arthritis, joint pain Skin: rash, pruritus, acne, urticaria, discolored skin and sweat Other: edema InteractionsDrug-drug. Amitriptyline, anticoagulants, barbiturates, beta-adrenergic blockers, chloramphenicol, clofibrate, corticosteroids, cyclosporine, dapsone, delavirdine, diazepam, digoxin, diltiazem, disopyramide, doxycycline, fentanyl, fluconazole, fluoroquinolones, haloperidol, hormonal contraceptives, indinavir, itraconazole, ketoconazole, methadone, mexiletine, nelfinavir, nifedipine, nortriptyline, oral hypoglycemics, phenothiazines, progestin, quinidine, quinine, ritonavir, saquinavir, sildenafil, tacrolimus, theophylline, thyroid preparations, tocainide, verapamil, warfarin, zidovudine: decreased actions of these drugs Antiretroviral drugs: decreased efficacy of these drugs Drug-diagnostic tests. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, eosinophils, lactate dehydrogenase, potassium, uric acid: increased levels Folate, vitamin B12 assays: interference with standard assays Hemoglobin, neutrophils, platelets, white blood cells: decreased values Patient monitoring• Monitor CBC, uric acid level, and liver function tests. Watch for signs and symptoms of blood dyscrasias and hepatitis. Patient teaching☞ Instruct patient to immediately report fever, malaise, appetite loss, nausea, vomiting, or yellowing of skin or eyes. rifapentine Priftin® Infectious disease An agent used for pulmonary TB and MAC with other agents–INH, pyrazinamide, ethambutol, streptomycin. See AIDS, Tuberculosis. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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