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Richter syndrome

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Richter syndrome
The development of a clinically aggressive pleomorphic large–usually B cell–lymphoma in the background of CLL–which occurs in 3-10% of CL or Waldenström's macroglobulinemia Clinical Rapid onset of intractable fever, weight loss, lymphadenopathy, hepatosplenomegaly


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In survival analyses, active leukemia, disease-associated infections, Richter syndrome, bone marrow failure, and second primary malignancies were considered as causes for CLL-related deaths.
Richter syndrome is defined as the development of a large cell lymphoma in patients with chronic lymphocytic leukemia, and this transformation is characterized by rapid deterioration in the patient's general condition, lymphadenopathy, and hepatosplenomegaly.
 
 
 
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