ribozyme

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ri·bo·zyme

(rī'bō-zīm),
A nonprotein RNA biocatalyst; several cleave precursors of tRNA to yield functional tRNAs; others act on rRNA; plays a key role in intron splicing events.
Synonym(s): organic catalyst (1) , RNA enzyme
[ribonucleic acid + -zyme]

ribozyme

(rī′bə-zīm′)
n.
An RNA molecule that acts as a catalyst, especially for the cleavage of RNA strands at specific sites.

ribozyme

One of a unique class of RNA molecules that can act as cleaving enzymes in addition to storing genetic information. This is a notable exception to the general rule that all enzymes are proteins. Ribozymes form complementary base pairs in the normal manner but can cleave segments of nascent RNA during the splicing process of the formation of mature RNA transcripts of DNA. Ribozymes can be used in various ways as treatment modalities.

ribozyme

an RNA molecule with catalytic activity. Ribozymes include (a) molecules involved in processing RNA precursor molecules by cleaving PHOSPHODIESTER BONDS, for example in self-SPLICING of some precursor rRNA INTRONS; and (b) molecules catalysing key cellular reactions, for example rRNA of the large ribosomal subunit (see RIBOSOME), which is closely involved with the peptidyl transferase activity that catalyses PEPTIDE BOND formation in TRANSLATION. Ribozymes are found in EUCARYOTES, PROKARYOTES, VIRUSES and VIROIDS.

ribozyme

enzyme whose catalytic function is carried out by an RNA subunit; of the four known classes, three carry out self processing reactions while the fourth, ribonuclease P (RNase P), is a true catalyst; discovered in the context of RNA splicing.
References in periodicals archive ?
No one had ever made or even tried to make a ribozyme that worked cross-chirally, on opposite-handed RNA.
Moreover, the researchers found that the viral load of mice treated with the ribozyme-carrying Salmonella was 400- to 600-times lower than the viral load for mice given the defective ribozymes and for mice that were untreated.
In this instance the level of vif expression in cells transfected with the catalytic and non-catalytic ribozymes appeared to be the same.
The switch works in concert with a ribozyme contained in the same mRNA molecule.
Ribozymes have been proposed for treatment of a variety of diseases, including infectious diseases and cancer.
RPI is partnered with Chiron Corporation for the development and commercialization of ANGIOZYME(R), an anti-angiogenic ribozyme designed to inhibit the growth of new vasculature to supply blood to tumors and prevent tumor growth and metastasis, which is also in two Phase II clinical trials.
Ribozyme is partnered with Chiron Corporation (Emeryville, CA) for the development and commercialization of ANGIOZYME, an anti-angiogenic ribozyme designed to inhibit the growth of new vasculature to supply blood to tumors and prevent tumor growth and metastasis, which is also in two Phase II clinical trials.
The molecule, which he calls a "functional ribozyme mimic," uses water molecules, abundant in cells, in a chemical reaction to attack specific, targeted sequences of mRNA.
These ribozymes will attack the target, cut it, destroy it, and then recycle themselves and attack more.
If a ribozyme like the Diels-Alderase is capable of doing organic chemistry to build up complex molecules, then potentially something like that could have been present to create the building blocks of life," said Smith.
Previously, our lab designed and cloned a number of hammerhead ribozymes targeted to the tat genomic sequence of the HIV-1 genomic clone NL43.
Cambridge, MA; 617-679-5500) announced the issuance of a United States patent that contains broad claims covering ribozymes with 2'-O-methyl modifications.