ROCK1

(redirected from Rho-associated, coiled-coil-containing protein kinase 1)

ROCK1

A gene on chromosome 18q11.1 that encodes a protein kinase, which is a key regulator of actin cytoskeleton and cell polarity. It regulates smooth muscle contraction, actin cytoskeleton organisation, stress-fibre and focal adhesion formation, and neurite retraction, as well as cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. It phosphorylates FHOD1, and both promote SRC-dependent non-apoptotic plasma membrane blebbing. ROCK1 also: phosphorylates JIP3 and regulates JNK to JIP3 recruitment in response to UVB-induced stress; suppresses inflammatory cell migration by regulating PTEN phosphorylation and stability; downregulates VEGF-induced angiogenic endothelial cell activation; promotes keratinocyte terminal differentiation; and plays a role in terminal erythroid differentiation. ROCK1 is required for centrosome positioning and centrosome-dependent exit from mitosis. It may regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles.
References in classic literature ?
Let the end come as it may, here I am ready to profit by it: here I am, facing both ways, with perfect ease and security -- a moral agriculturist, with his eye on two crops at once, and his swindler's sickle ready for any emergency.
Then they rushed on and met those of the Slayers who stood before them, and the men of Dingaan were swept away and scattered by Groan-Maker and the Watcher, as dust is swept of a wind, as grass is swept by a sickle.
There was nothing in the way of fighting that Kala Nag, the old wise Black Snake, did not know, for he had stood up more than once in his time to the charge of the wounded tiger, and, curling up his soft trunk to be out of harm's way, had knocked the springing brute sideways in mid-air with a quick sickle cut of his head, that he had invented all by himself; had knocked him over, and kneeled upon him with his huge knees till the life went out with a gasp and a howl, and there was only a fluffy striped thing on the ground for Kala Nag to pull by the tail.
The cost of an efficient farm system is now so little-- not more than two dollars a month, that the present trashy lines are certain sooner or later to go to the junk-heap with the sickle and the flail and all the other cheap and unprofitable things.
The hilltop, the cool air of the night, the company of the great monuments, the sight of the city under his feet, with its hills and valleys and crossing files of lamps, drew him by all he had of the poetic, and he turned that way; and by that quite innocent deflection, ripened the crop of his venial errors for the sickle of destiny.
Any farmer, on viewing it, would have said that Jason must wait weeks before the green blades would peep from among the clods, and whole months before the yellow grain would be ripened for the sickle.
He wrought also a field of harvest corn, and the reapers were reaping with sharp sickles in their hands.
It broke in wild yells, and a rush up the street of men and women, waving clubs and bamboos and sickles and knives.
It was an Abyssinian or Nubian production of a bizarre shape; the clumsiest thing imaginable, partaking of a sickle and a chopper with a sharp edge and a pointed end.
He who wants to be a sickle must bend himself betimes.
Ay, you may mow down the leaves and the blossoms, but the roots of life lie too deep for your sickle to sever.
They merely wore a gayer air than was their wont, and some weapon could be seen glittering between the legs of each of them,--a sickle, an axe, a big two-edged sword or the hook of an old hackbut.