ROCK2

(redirected from Rho kinase 2)

ROCK2

A gene on chromosome 2p24 that encodes a protein kinase which is a key regulator of actin cytoskeleton and cell polarity. It regulates smooth muscle contraction, actin cytoskeleton organisation, stress-fibre and focal adhesion formation, and neurite retraction, as well as cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, DPYSL2, EP300, EZR, IRF4, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A, SORL1 and VIM. It downregulates VEGF-induced angiogenesis.
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5m grant, the third year installment to continued research into BioAxone's first-in-class selective Rho Kinase 2 (ROCK2) inhibitor, BA-1049, a drug in development to treat cerebral cavernous malformations (CCM), the company said.
In preclinical experiments BA-1049, a first-in-class oral inhibitor of Rho kinase 2 (ROCK2), has shown promise to repair the leaky endothelial cell barrier and potentially to reverse progression of disease.
US-based biotechnology company BioAxone BioSciences, Inc has entered a contract with US-based Wilmington PharmaTech to manufacture the company's BA-1049, a selective inhibitor of Rho kinase 2 (ROCK2), the company said.