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Rh system

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Rh system
Transfusion medicine A family of blood group antigens that can cause fatal transfuion reactions if improperly matched Frequency of Rh antigens–whites Rh-e, 98%; Rh-D, 85%; Rh-c, 80%; Rh-C, 70%; Rh-E, 30%; Rh-D exposure is important in OB–an Rh-D-negative mother's anti-RH-D antibody is an IgG which may cross the placenta, and cause HDN–titer > 1:16 in the 8th month indicates maternal formation of alloantibodies, evidenced by stomatocytes in mom's blood; the Rh type is determined prenatally by PCR of amniotic cells Prophylaxis 300 µg of anti-D–RhoGAM neutralizes 30 ml feto-maternal hemorrhage containing 15 ml of Rh+ RBCs. See Blood group, Hemolytic disease of newborn, Rh immune globulin.


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Over 70 years ago, Ortho Products' research led to breakthroughs in understanding the Rh system in human blood.
Perrault's professional publications reflect his significant research efforts into such areas as blood freezing, blood component therapy, antibody analysis, the Rh system, hepatitis, retroviruses and AIDS.
The number of alleles in the ABO and Rh blood group systems, and the low antigenicity of all but the D antigen in the Rh system, make it relatively easy to supply blood in virtually unlimited quantities to patients requiring hemotherapy.
 
 
 
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