Rh incompatibility


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Related to Rh incompatibility: Rh factor, Rhogam, Coombs test, ABO incompatibility

Rh incompatibility

the agglutination (clumping together) of red blood cells as a result of mixing different antigens (agglutinogens) present on the surface of the cells. This agglutination is an immune reaction and depends on the formation of antibodies against the specific agglutinogen (Rh factor) present on the red blood cells and in blood from a transfusion or fetal tissues. The immune reaction does not occur immediately, but depends on the gradual formation of antibodies. For example, a D-negative (Rh negative) person who has been previously exposed to D-positive red cells through transfusion or pregnancy may produce anti-D, and therefore be incompatible with all D-positive (Rh positive) red cells. See also Rh factor.

Rh incompatibility

 Transfusion medicine An incompatibility in Rh types between a donor and recipient, or between an fetus–who is Rh positive, and the mother–who is negative and produces antibodies against the fetus' RBCs, which pass to the placenta, and cause HDN. See Hemolytic disease of the newborn.

Rh incompatibility,

n a condition in which two groups of blood cells are antigentically different because of the presence of Rh factor in one group and the absence of the Rh factor in the other. See also Rh factor.
References in periodicals archive ?
Genes determine whether an individual possesses RhD-positive or RhD-negative antigens, so Rh incompatibility probably clusters in some families.
The Company is using its patented Transrenal DNA-based technology platform to develop a number of medical tests for infectious diseases including AIDS and tuberculosis, and for prenatal genetic testing, including gender determination, Rh incompatibility and Down syndrome.
The medicines produced by PPTA members are used in treating life-threatening diseases and serious medical conditions including bleeding disorders, immune system deficiencies, alpha-1 antitrypsin deficiencies, rabies, tetanus, rh incompatibility, burns and shock.
The company provides value-added, antibody-based products that are used as the active ingredients in therapeutic products for the treatment and management of diseases such as Rh incompatibility in newborns, rabies and hepatitis and in diagnostic products such as blood typing reagents and diagnostic test kits.