Printer Friendly
Dictionary, Encyclopedia and Thesaurus - The Free Dictionary
3,900,941,586 visitors served.
forum Join the Word of the Day Mailing List For webmasters
?
Dictionary/
thesaurus
Medical
dictionary
Legal
dictionary
Financial
dictionary
Acronyms
 
Idioms
Encyclopedia
Wikipedia
encyclopedia
?

fork
(redirected from Replication fork)

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia 0.01 sec.
fork (fork) a pronged instrument.
replication fork  a site on a DNA molecule at which unwinding of the helices and synthesis of daughter molecules are both occurring.
Enlarge picture
Replication fork, showing simultaneous synthesis of both strands; since synthesis occurs in the 5′ to 3′ direction, one strand, the leading strand, can be synthesized continuously while the other, the lagging strand, must be synthesized discontinuously in short fragments (Okazaki fragments) which are later joined.
tuning fork  a device that produces harmonic vibration when its two prongs are struck; used to test hearing and bone conduction.

fork
[fôrk]
Etymology: L, furca
1 an instrument with prongs.
2 something resembling such an instrument.

fork [fork]
a pronged instrument.
tuning fork a device that produces harmonic vibration when its two prongs are struck; used to test hearing and bone conduction. See tuning fork tests.


Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content.
?Page tools
Printer friendly
Cite / link
Feedback
Add definition
Mentioned in?  References in periodicals archive?   Medical browser?   Full browser?
 
Others have linked sensitivity to low doses of camptothecin to heightened sensitivity of cells in S phase (43) and have provided evidence that camptothecin-induced DSBs resulting from stalled replication forks are resolved by homologous recombination (39, 44).
In both cases, fluoroquinolones appear to trap the enzyme on DNA during the topoisomerization reaction, forming a physical barrier to the movement of the replication fork (4), RNA polymerase (5), and DNA helicase (6).
The article, "A DNA Replication Mechanism for Generating Nonrecurrent Rearrangements Associated with Genomic Disorders," describes a newly discovered mechanism for human genomic disorders called replication Fork Stalling and Template Switching (FoSTeS) in which segments of DNA are added or deleted in previously unexpected locations during replication.
 
 
 
Medical Dictionary
?

Terms of Use | Privacy policy | Feedback | Advertise with Us | Copyright © 2012 Farlex, Inc.
Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.