lagging strand

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lagging strand

In DNA replication, the single strand forming a duplex in the direction away from the fork in the parental DNA. Replication on the lagging strand is discontinuous and can occur briefly in both directions.

lagging strand

the strand in DNA replication that is synthesized discontinuously, to generate Okazaki fragments (named after R. Okazaki who first detected them). These are later sealed by DNA LIGASE. See DNA, SEMICONSERVATIVE REPLICATION MODEL.

strand

a term commonly used to describe one of the two complementary polynucleotide chains found in double-stranded DNA.

lagging strand
in DNA replication, the strand in which the nascent strand is synthesized in discontinuous segments after the other or leading strand. See also okazaki fragments.
leading strand
in DNA replication, the strand that is copied continuously.
References in periodicals archive ?
1999) Elimination of replication fork block protein Fob1 extends the life span of yeast mother cells.
DNA strand cleavage is required for replication fork arrest by a frozen topoisomerase-quinolone-DNA ternary complex.
Finally, we will explore the relationship between DDT, replication fork architecture and sister chromatid cohesion in the context of DDR- and SUMO-orchestrated DNA transactions.
We will use these in vitro replication systems together with both established and novel chromatin assembly systems to understand: a) how chromatin influences replication origin choice and timing, b) how nucleosomes on parental chromosomes are disrupted during replication and are distributed to daughter chromatids, and c) how chromatin states and gene expression patterns are re-established after passage of the replication fork.
We plan: a) to identify the proteins and mechanism that actively works in the formation and prevention of intermediates responsible for R-loop-mediated TAR; b) to define the histone residues linked to R-loop formation and its role in chromatin dynamics, and c) to establish how the different trans and cis elements control genome-wide R-loop mediated genome instability whether or not in association with replication fork impairment, double-strand break accumulation, chromatin structure and mRNP biogenesis and export.