renin-angiotensin system

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re·nin-an·gi·o·ten·sin sys·tem

a selective regulator of the aldosterone biosynthetic pathway that acts by increasing aldosterone production and sodium retention as a result of volume depletion, with resulting increased renin production in the kidney and conversion of angiotensin I in the plasma to angiotensin II.

renin-angiotensin system

the regulation of sodium balance, fluid volume, and blood pressure. In response to reduced perfusion, renin is secreted, which hydrolyzes a plasma globulin to release angiotensin I, which is rapidly hydrolyzed to angiotensin II, a powerful vasoconstrictor; angiotension II also stimulates aldosterone secretion, which causes sodium retention, an increase in blood pressure, and restoration of renal perfusion, which shuts off the signal for renin release (negative feedback). Angiotensin-converting enzyme also deactivates bradykinin, a vasodilator. Also called renin-angiotensin-aldosterone system.
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Renin-angiotensin system

re·nin-an·gi·o·ten·sin sys·tem

(RAS) (rē'nin-an-jē-ō-tensin sistĕm)
Selective regulator of the aldosterone biosynthetic pathway that acts by increasing aldosterone production and sodium retention due to volume depletion.

renin

a proteolytic enzyme synthesized, stored and secreted by the juxtaglomerular cells of the kidney; it plays a role in regulation of blood pressure by catalyzing the conversion of the plasma glycoprotein angiotensinogen to angiotensin I. This, in turn, is converted to angiotensin II by an enzyme that is present in relatively high concentrations in the lung. Angiotensin II is one of the most potent vasoconstrictors known, and also is a powerful stimulus of aldosterone secretion.

renin-angiotensin system
renin, secreted by the juxtaglomerular apparatus, activates the precursor angiotensinogen. This liberates angiotensin I, then angiotensin II, a vasoconstrictor and stimulant to the secretion of aldosterone.
big renin
a relatively inactive protein with a higher molecular weight than normal renin, which is activated after exposure to low pH or to proteolytic enzymes.
References in periodicals archive ?
Herzig also explained in detail about the Renin-Angiotensin System (RAS) and The Frank-Starling Law of the heart.
The discovery that modulating the renin-angiotensin system also reduces digestive efficiency may lead to the developments of new anti-obesity treatments.
The ACE works in the renin-angiotensin system to increase blood pressure.
1) Drugs that act directly on the renin-angiotensin system can cause injury and death to a developing fetus.
The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition, J Manag Care Pharm.
1,25-Dihydroxyvitamin D3 is a negative endocrine regulator of the renin-angiotensin system.
Drugs like angiotensin-converting enzyme inhibitors (ACEIs) lower blood pressure by inhibiting the activity of the renin-angiotensin system (RAS).
In general, only SD receiving maitake SX, not the two drugs, showed decreased activity of the renin-angiotensin system and increased NO system activity compared with control under the conditions examined.
The renin-angiotensin system (RAS) is a major regulator of blood pressure and vascular response to injury.
Just under half (45%; 298/663) were taking statins, and 39% (259/663) were taking inhibitors of the renin-angiotensin system.
It has been demonstrated that vitamin D has a high impact on congestive heart failure main risk factors as hypertension, renin-angiotensin system malfunction and atherosclerosis.
Randomised controlled trial of dual blockade of renin-angiotensin system in patients with hypertension, microalbu-minuria, and non-insulin dependent diabetes: the candesartan and lisinopril microalbuminuria (CALM) study.