renal cell carcinoma


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carcinoma

 [kahr″sĭ-no´mah] (pl. carcinomas, carcino´mata)
a malignant new growth made up of epithelial cells tending to infiltrate surrounding tissues and to give rise to metastases. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue.
adenocystic carcinoma (adenoid cystic carcinoma) carcinoma marked by cylinders or bands of hyaline or mucinous stroma separated or surrounded by nests or cords of small epithelial cells, occurring in the mammary and salivary glands, and mucous glands of the respiratory tract. Called also cylindroma.
alveolar carcinoma bronchioloalveolar carcinoma.
basal cell carcinoma the most common form of skin cancer, consisting of an epithelial tumor of the skin originating from neoplastic differentiation of basal cells, rarely metastatic but locally invasive and aggressive. It usually occurs as small pearly nodules or plaques on the face of an older adult, particularly on a sun-exposed area of someone with fair skin. It has been divided into numerous subtypes on the basis of clinical and histological characteristics.
basosquamous carcinoma carcinoma that histologically exhibits both basal and squamous elements.
bronchioalveolar carcinoma (bronchiolar carcinoma) (bronchioloalveolar carcinoma) (bronchoalveolar carcinoma) a variant type of adenocarcinoma of the lung, with columnar to cuboidal epithelial cells lining the alveolar septa and projecting into alveolar spaces in branching papillary formations. Called also alveolar carcinoma or adenocarcinoma and bronchiolar, bronchioloalveolar, or bronchoalveolar adenocarcinoma.
bronchogenic carcinoma any of a large group of carcinomas of the lung, so called because they arise from the epithelium of the bronchial tree. Four primary subtypes are distinguished: adenocarcinoma of the lung, large cell carcinoma, small cell carcinoma, and squamous cell carcinoma.
cholangiocellular carcinoma a rare type of hepatocellular carcinoma arising from the cholangioles, consisting of two layers of cells surrounding a minute lumen. Called also bile duct carcinoma and cholangiocarcinoma.
chorionic carcinoma choriocarcinoma.
colloid carcinoma mucinous carcinoma.
cylindrical cell carcinoma carcinoma in which the cells are cylindrical or nearly so.
embryonal carcinoma a highly malignant germ cell tumor that is a primitive form of carcinoma, probably of primitive embryonal cell derivation; it usually arises in a gonad and may be found either in pure form or as part of a mixed germ cell tumor.
epidermoid carcinoma squamous cell carcinoma.
giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs.
hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. It is rare in North America and Western Europe but is one of the most common malignancies in parts of sub-Saharan Africa, Southeast Asia, East Asia, and elsewhere. A strong association seems to exist with chronic hepatitis B virus infection.
Hürthle cell carcinoma a malignant Hürthle cell tumor.
carcinoma in si´tu a neoplasm whose tumor cells are confined to the epithelium of origin, without invasion of the basement membrane; the likelihood of subsequent invasive growth is presumed to be high.
large cell carcinoma a type of bronchogenic carcinoma of undifferentiated (anaplastic) cells of large size, a variety of squamous cell carcinoma that has undergone further dedifferentiation.
medullary carcinoma that composed mainly of epithelial elements with little or no stroma.
mucinous carcinoma an adenocarcinoma that produces significant amounts of mucin.
nasopharyngeal carcinoma a malignant tumor arising in the epithelial lining of the nasopharynx, occurring at high frequency in people of Chinese descent. The epstein-barr virus has been implicated as a causative agent.
non–small cell carcinoma a general term comprising all lung carcinomas except small cell carcinoma, and including adenocarcinoma of the lung, large cell carcinoma, and squamous cell carcinoma.
oat cell carcinoma a form of small cell carcinoma in which the cells are round or elongated and slightly larger than lymphocytes; they have scanty cytoplasm and clump poorly.
papillary carcinoma carcinoma in which there are papillary growths that are irregular in nature arising from otherwise normal tissue; it can occur in the thyroid gland, the breast, or the bladder. Called also papillocarcinoma.
renal cell carcinoma carcinoma of the renal parenchyma, composed of tubular cells in varying arrangements; called also clear cell carcinoma.
scirrhous carcinoma carcinoma with a hard structure owing to the formation of dense connective tissue in the stroma. Called also fibrocarcinoma.
carcinoma sim´plex an undifferentiated carcinoma.
small cell carcinoma a common, highly malignant form of bronchogenic carcinoma in the wall of a major bronchus, occurring mainly in middle-aged individuals with a history of tobacco smoking; it is radiosensitive and has small oval undifferentiated cells. Metastasis to the hilum and to mediastinal lymph nodes is common.
spindle cell carcinoma squamous cell carcinoma marked by development of rapidly proliferating spindle cells.
squamous cell carcinoma
1. carcinoma developed from squamous epithelium, having cuboid cells and characterized by keratinization. Initially local and superficial, the lesion may later invade and metastasize.
2. the form occurring in the skin, usually originating in sun-damaged areas or preexisting lesions.
3. in the lung, one of the most common types of bronchogenic carcinoma, generally forming polypoid or sessile masses that obstruct the airways of the bronchi. It usually occurs in middle-aged individuals with a history of smoking. There is frequent invasion of blood and lymphatic vessels with metastasis to regional lymph nodes and other sites. Called also epidermoid carcinoma.
transitional cell carcinoma a malignant tumor arising from a transitional type of stratified epithelium, usually affecting the urinary bladder.
verrucous carcinoma
1. a variety of squamous cell carcinoma that has a predilection for the buccal mucosa but also affects other oral soft tissue and the larynx. It is slow-growing and somewhat invasive.
2. Buschke-Löwenstein tumor, so called because it is histologically similar to the oral lesion.

re·nal ad·e·no·car·ci·no·ma

an adenocarcinoma arising in the renal parenchyma, usually occurring in middle-aged or older people of either gender (although more common in men).

renal cell carcinoma

a malignant neoplasm of the kidney. Also called adenocarcinoma of the kidney, clear cell carcinoma of the kidney. See also kidney cancer, Wilms' tumor.

renal cell carcinoma

Adenocarcinoma of renal cells, hypernephroma, kidney cancer, renal cancer, renal cell cancer, renal adenocarcinoma Oncology A renal tubule CA Epidemiology 30,600 new, 12,000 deaths/yr–US, 1996 Risk factors 1.6 ♂, 1.9 ♀, obesity in ♀–5.9 odds ratio in highest 5% of upper body mass, phenacetin analgesics, ↑ meat consumption, tea drinking–♀, petroleum exposure Types Clear cell–75%-80%, papillary–types 1, 2–10%-15%, chromophobe–5%, oncocytoma–5% Diagnosis Hx, exam, imaging, Bx Management Surgery, RT, chemotherapy are ineffective; IL-2 and IFN alpha yield a 20% response, 20% 1 yr event-free survival

Renal cell carcinoma

Cancer of the kidney.
Mentioned in: Nephrectomy
References in periodicals archive ?
The FDA's Breakthrough Therapy Designation for the LENVIMA and KEYTRUDA combination in advanced and/or metastatic renal cell carcinoma provides us with the opportunity to accelerate our effort to bring an important potential treatment option to these patients," said Dr.
In a comment, I state that the differential includes both an oncocytoma and a low-grade indolent renal cell carcinoma and that the atypia in the tumor is somewhat beyond what is typically seen in an oncocytoma; therefore, the patient may benefit from some clinical follow-up.
Loss of chromosome analysis at 3p in clear cell renal cell carcinoma with or without elevated pretreatment C-reactive protein
Any renal mass that enhances with intravenous administration of contrast material on CT scanning by more than 15 hounsfield units (HU) should be considered a renal cell carcinoma (RCC) until proved otherwise1,2.
Renal cell carcinoma metastases to the skin: A not so rare case?
Sharma, "Solitary delayed contralateral testicular metastasis from renal cell carcinoma," Indian Journal of Pathology and Microbiology, vol.
In such cases then immediately carryout intravenous pyelography and followed by post contrast CT scan abdomen for extension and localization of tumor so as to consider nephron sparing surgery can be possible or not10,11, as was seen in our case in which early diagnosis of duplex kidney with lower moiety renal cell carcinoma which has spared the lower moiety pelvi-calyceal system as well as upper moiety pelvi-calyceal system, making nephron sparing surgery possible with good prognosis.
This study was undertaken to share our experience regarding the outcome of radical nephrectomy in the management of localized renal cell carcinoma.
Within this context, this case report aims to highlight the pathological characteristics of this rare subtype of renal cell tumors and to point out the differential diagnosis--particularly with the papillary renal cell carcinoma, given the different prognosis and therapeutic approach of these two entities.
EXCLUSION CRITERIA: All the patients with renal cell carcinoma under the age of 18 are excluded.
The report provides a snapshot of the global therapeutic landscape of Renal Cell Carcinoma