Regaine


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minoxidil

Apo-Gain (CA), Gen-Minoxidil (CA), Loniten (UK) (CA), Minox (CA), Regaine (UK), Rogaine, Rogaine Extra Strength

Pharmacologic class: Peripheral vasodilator (direct-acting)

Therapeutic class: Antihypertensive, hair growth stimulant

Pregnancy risk category C

FDA Box Warning

• Drug may cause serious adverse effects (such as pericardial effusion occasionally progressing to tamponade) and may exacerbate angina pectoris. Reserve it for hypertensive patients who respond inadequately to maximum therapeutic doses of diuretic and two other antihypertensives.

• Give under close supervision, usually concurrently with therapeutic doses of beta blocker to prevent tachycardia and increased myocardial workload. Usually, drug also must be given with diuretic to prevent serious fluid accumulation. Patients with malignant hypertension and those already receiving guanethidine should be hospitalized when therapy begins so they can be monitored to avoid too rapid, or large orthostatic, blood pressure decreases.

Action

Reduces blood pressure by relaxing vascular smooth muscle, causing vasodilation. Action in hair growth stimulation unclear; vasodilatory action may enhance microcirculation around hair follicles.

Availability

Tablets: 2.5 mg, 10 mg

Topical solution: 2%, 5%

Indications and dosages

Severe symptomatic hypertension; hypertension associated with end-organ damage

Adults and children ages 12 and older: 5 mg/day as a single dose, increased carefully q 3 days. Usual range is 10 to 40 mg/day in single or divided doses. For rapid blood pressure control with careful monitoring, dosage may be adjusted q 6 hr. Maximum dosage is 100 mg/day.

Children younger than age 12: 0.2 mg/kg/day P.O. as a single dose. May increase in increments of 50% to 100% until blood pressure control is optimal. Usual range is 0.25 to 1 mg/kg/day; maximum recommended dosage is 50 mg/day.

Male-pattern baldness; diffuse hair loss or thinning in women; adjunct to hair transplantation

Adults: Apply 1 ml of 2% or 5% topical solution to affected area b.i.d. for 4 months or longer.

Alopecia areata

Adults: Apply 1 ml of 2% or 5% topical solution to scalp b.i.d.

Contraindications

• Hypersensitivity to drug or its components
• Dissecting aortic aneurysm
• Pheochromocytoma

Precautions

Use cautiously in:
• recent MI, malignant hypertension, heart failure, angina pectoris, severe renal impairment
• concurrent guanethidine therapy
• pregnant or breastfeeding patients.

Administration

• Give oral form with meals to decrease GI upset.

If patient is also receiving guanethidine, discontinue that drug 1 to 3 days before starting minoxidil, to avoid severe orthostatic hypotension.
• Know that oral form is usually given with a beta-adrenergic blocker or diuretic to control hypertension.

Adverse reactions

CV: ECG changes (such as T-wave changes), tachycardia, angina, pericardial effusion, cardiac tamponade, heart failure

GI: nausea, vomiting

Respiratory: pulmonary edema

Skin: hypertrichosis

Other: weight gain, edema

Interactions

Drug-drug.Antihypertensives, nitrates: additive hypotension

Guanethidine: severe orthostatic hypotension

Nonsteroidal anti-inflammatory drugs: decreased minoxidil efficacy

Drug-diagnostic tests.Alkaline phosphatase, blood urea nitrogen, creatinine, plasma renin activity, sodium: increased levels

Hematocrit, hemoglobin, red blood cells: decreased levels

Patient monitoring

• Monitor vital signs and ECG.
• Assess daily weight and fluid intake and output.

Monitor cardiovascular status carefully. Stay alert for signs and symptoms of heart failure.
• Watch for hypertrichosis.
• Know that hematologic and renal values usually return to pretreatment levels with continued therapy.

Patient teaching

• Instruct patient to take oral form with meals to decrease GI upset.
• Advise patient to weigh himself daily and report sudden gains.
• Tell patient taking oral form that drug may darken, lengthen, and thicken body hair. Tell him to shave or use depilatory to reduce unwanted hair growth. Reassure him that unwanted growth will disappear 1 to 6 months after he stops taking drug.

Instruct patient to immediately report difficulty breathing (especially when lying down) or pain in chest, arm, or shoulder.
• Teach patient how to use topical form. Urge him to read package insert carefully.
• Caution patient not to use topical form on other body parts and not to let it contact mucous membranes.
• Tell patient using topical form that new scalp hair will be soft and barely visible. Caution him to use only 1 ml twice daily, regardless of amount of balding. Remind him not to stop using drug suddenly, because new hair growth will be lost.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

Regaine

Rogaine, a brand name for MINOXIDIL in a preparation for external use as a hair restorer.
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References in periodicals archive ?
Last night, a company spokeswoman said: ``The Regaine UK advertising campaign is not based on one myth but a whole variety of different myths from many countries around the world.
Ninety-two percent of the subjects rated Regaine excellent, good or fair in slowing or stopping hair loss after one year of use.
Membership of Hairline costs pounds 12 and drugs, such as Regaine, cost pounds 25 for a month's supply.
They were not aware of Regaine, the only clinically proven hereditary hair loss treatment for men available to buy at pharmacies or online.
Apart from whether or not cow's saliva works in this way and the hope that in a sweet ironic future scientists learn that it is actually more effective than the chemical goo Regaine would have us smear over our gleaming pates, the advert was just another example of the lazy prejudice which gets hurled from time to time at Wales.
Regaine (Minoxidil) is a drug which can slow, or reverse, hair loss by interfering with the chemical that causes hair follicles to shut down.
Regaine paint, available from your chemist, and Propecia tablets, which are only available on private prescription at up to pounds 1-a-day.
I've just phoned your helpline on hair loss in men and was surprised to hear you say that Regaine was the only licensed product available in the UK to treat baldness.
Although irreversible, it can be lessened by using Regaine.
Outside the United States, Rogaine Extra Strength for Men is marketed to both men and women under the brand name Regaine in 14 countries, including two countries as a non-prescription product.
Now she has launched a pounds 1 million damages claim against the makers of the hair-growing solution, Regaine.
1 Regaine Extra Strength Foam, EUR44, 60ml, Boots This hair hero contains minoxidil - a clinically proven over-the-counter ingredient to treat hereditary hair loss.