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refractory anemia with excess blasts

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refractory anemia with excess blasts
Hematology A myelodysplastic syndrome of older persons characterized by anemia or pancytopenia and BM hypercellularity Clinical Nonspecific–anemia of gradual onset, fatigue, weakness, exacerbation of underlying heart disease Lab Anisocytosis, megaloblastoid maturation of erythroid precursors, thrombocytopenia; 5-20% of the BM cells are blasts; < 5% of peripheral cells are blasts Prognosis Guarded; average Pt survives < 1 yr; ±1⁄4 undergo leukemic transformation, usually into ANLL Treatment Not all Pts require therapy;1⁄3 die of bleeding or infectious complication linked to pancytopenia; intensive chemotherapy may substitute one cause of M&M for another; cytokines and growth factors may be effective. See Myelodysplastic syndrome, PISA.
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12) As a subgroup of the myelodysplastic syndromes, CMML shares the characteristics of trilineage dysplasia with refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, and refractory anemia with excess blasts in transformation.
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These subtypes include: refractory anemia (RA), Refractory anemia with ringed sideroblasts (RARS) if accompanied by neutropenia, or thrombocytopenia or requiring transfusions, Refractory anemia with excess blasts (RAEB), Refractory anemia with excess blasts in transformation (RAEB-T), and chronic myelomonocytic leukaemia (CMML).
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These subtypes include: refractory anemia (RA) or refractory anemia with ringed sideroblasts (RARS) if accompanied by neutropenia or thrombocytopenia or requiring transfusions; refractory anemia with excess blasts (RAEB), refractory anemia with excess blasts in transformation (RAEB-T), and chronic myelomonocytic leukaemia (CMML).
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