Reed-Sternberg cell

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Reed-Stern·berg cell

(rēd shtĕrn'bĕrg),
large transformed lymphocytes, probably B cell in origin, generally regarded as pathognomonic of Hodgkin disease; a typical cell has a pale-staining acidophilic cytoplasm and one or two large nuclei showing marginal clumping of chromatin and unusually conspicuous deeply acidophilic nucleoli; binucleate Reed-Sternberg cell frequently shows a mirror-image form (mirror-image cell).

Reed-Sternberg cell

(rēd′stûrn′bûrg′)
n.
A large, abnormal, binucleated or multinucleated B cell that is characteristic of Hodgkin lymphoma.

Reed-Sternberg cell

Etymology: Dorothy M. Reed, American pathologist, 1874-1964; Karl Sternberg, Austrian pathologist, 1872-1935
one of a number of large, abnormal, multinucleated reticuloendothelial cells in the lymphatic system found in Hodgkin's disease. The number and proportion of Reed-Sternberg cells identified are the basis for the histopathological classification of Hodgkin's disease.
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Reed-Sternberg cell

Reed-Stern·berg cell

(rēd-stĕrn'bĕrg sel)
Large transformed lymphocytes, probably B cell in origin, generally regarded as pathognomonic of Hodgkin lymphoma; a typical cell has a pale-staining acidophilic cytoplasm and one or two large nuclei showing marginal clumping of chromatin and unusually conspicuous deeply acidophilic nucleoli; binucleate Reed-Sternberg cells frequently show a mirror-image form (mirror-image cell).
Enlarge picture
REED-STERNBERG CELL: Reed-Sternberg cell in Hodgkin Lymphoma

Reed-Sternberg cell

(rēd′stĕrn′bĕrg″)
[Dorothy Reed, U.S. pathologist, 1874–1964; Karl Sternberg, Aust. pathologist, 1872–1935]
A giant, malignant, multinucleated B lymphocyte, the presence of which is the pathologic hallmark of Hodgkin's disease.
See: illustration

Reed-Sternberg cell

A giant cell with paired, mirror-image nuclei that is a diagnostic feature of HODGKIN'S LYMPHOMA and distinguishes it from non-Hodgkin's lymphoma. (Dorothy M. Reed, 1874–1964, American pathologist; and Karl von Sternberg, 1872–1935, Austrian pathologist).

Reed-Sternberg cell

see Reed-Sternberg cell.
References in periodicals archive ?
The bone marrow biopsy showed infiltration by scattered Reed-Sternberg cells and mononuclear Hodgkin cells in reactive background consisting of small lymphocytes, epithelioid histiocytes, and occasional neutrophils and eosinophils (Figure 3).
Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription.
Demonstration of Epstein-Barr virus replication in Reed-Sternberg cells of Hodgkin's disease.
When Hodgkin's cells are examined microscopically, multinucleated Reed-Sternberg cells (RS cells) are the characteristic histopathology finding.
Hodgkin lymphoma (HL) is a malignant proliferation of Reed-Sternberg cells and their variants, Hodgkin cells, in an inflammatory cellular background, and is characterized by a progressive painless enlargement of lymph nodes.
Another tumor type associated with EBV is Hodgkin's disease, and EBV can be detected by PCR in some specimens within the characteristic Reed-Sternberg cells.
Hodgkin's disease is the only malignancy in which the tumor mass is not due to the number of malignant cells; that is, the Reed-Sternberg cells account for only 1% to 2% of the lymph node infiltrate (14, 21-24).
Hodgkin lymphoma, previously known as Hodgkin's disease, is a type of cancer originating from specific B-lymphocytes (white blood cells) called Reed-Sternberg cells.
Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.
However, review of the earlier histologic sections showed nodules composed of lacunar-type Reed-Sternberg cells, small lymphocytes, and plasma cells separated by birefringent collagen bands, findings more compatible with the nodular sclerosis type of HL.
The diagnosis is made when a biopsy of involved tissue reveals Reed-Sternberg cells.