These results "confirm our hypothesis that esomeprazole can effectively prevent recurrent ulcer
in clopidogrel users who have a peptic ulcer history," the investigators said.
A double-blind randomised controlled trial (5) which enrolled patients at high risk for recurrent ulcer
bleeding showed that a combination of a high-dose PPI (esomeprazole 20 mg twice daily) and celecoxib (200 mg twice daily) was significantly better than celecoxib alone in preventing GI complications.
Celecoxib versus diclofenac and omeprazole in reducing the risk of recurrent ulcer
bleeding in patients with arthritis.
The study found that the number of foot ulcers, recurrent ulcers
, duration of first ulcer, duration of recurrent ulcer
, total amputations, and mean cost per person increased with a VDT greater than or equal to 25V as compared to a VDT less than 25V.
Clopidogrel should not be substituted for aspirin in patients who have previous ulcer bleeding in an effort to reduce the risk of recurrent ulcer
Clopidogrel should not be substituted for aspirin as a strategy to reduce recurrent ulcer
bleeding in high-risk patients because it is inferior to the combination of aspirin plus PPIs.
pylori infection require treatment with anti-infective agents to address the third goal, whether on first presentation or with recurrent ulcer
The 13-month cumulative incidence of recurrent ulcer
bleeding in this trial was 0% in subjects randomized to the combination therapy, compared with 8.
The current approach to the treatment of recurrent ulcer
disease involves the administration of antibiotics.
of the Chinese University of Hong Kong and his associates reported that recurrent ulcer
bleeding occurred at a significantly higher rate in 161 patients who received clopidogrel (Plavix) plus a placebo than in 159 patients who received aspirin plus esomeprazole (Nexium) during a median follow-up of 12 months (8.
pylori eradication is associated with a low rate of recurrent ulcer
hemorrhage and suggest that H.
Neither celecoxib nor diclofenac plus omeprazole completely protects against recurrent ulcer
complications in high-risk arthritis patients, reported Dr.