thrombin (redirected from Receptors, thrombin)

thrombin /throm·bin/ (throm´bin)

1. the activated form of coagulation factor II (prothrombin); it catalyzes the conversion of fibrinogen to fibrin.

2. a preparation derived from prothrombin of bovine origin together with thromboplastin and calcium; used therapeutically as a local hemostatic.

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throm·bin (thrmbn)

n.

An enzyme in blood formed from prothrombin that facilitates blood clotting by reacting with fibrinogen to form fibrin. Also called thrombase.

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Thrombin

Thrombin is a protein produced by the body. It is a specific clotting factor that plays an important role in the blood clotting process.

Mentioned in: Anticoagulant and Antiplatelet Drugs, Fibrinogen Test, Prothrombin Time

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thrombin

[throm′bin]

an enzyme formed from prothrombin, calcium, and thromboplastin in plasma during the clotting process. Thrombin causes fibrinogen to change to fibrin, which is essential in the formation of a clot. Also called factor IIa. See also blood clot , prothrombin.

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thrombin [throm´bin]

1. the activated form of coagulation factor II (prothrombin), which catalyzes the conversion of fibrinogen to fibrin.

2. a preparation of this compound prepared from prothrombin of bovine origin, used as a topical hemostatic.

thrombin time (TT) the time required for plasma fibrinogen to form thrombin: exogenous thrombin is added to citrated plasma and the time to clot formation is measured. Prolonged TT is seen with abnormalities of fibrinogen and in the presence of heparin or degradation products of fibrin or fibrinogen.

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thrombin (throm´bin),

n a proteolytic enzyme formed from prothrombin by the action of thromboplastin, factor IV calcium (Ca⁺⁺), and other factors. Thrombin forms fibrin from fibrinogen, speeds up the disruption of platelets, and activates factor V.

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thrombin

an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets. A preparation from prothrombin of bovine origin is used as a topical hemostatic.

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thrombin-thrombomodulin complex

thrombomodulin, a specific endothelial cell surface receptor, converts thrombin, a very weak activator of protein C in the anticoagulant pathway, to the status of a very active protein C activator.

thrombin time

the time required for a standardized solution of thrombin to clot plasma. It is a measure of the rate of conversion of fibrinogen to fibrin.

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thrombin

Hematology A key clot promoting enzyme that converts fibrinogen to fibrin and protects against fibrinolysis by activating thrombin-activatable fibrinolysis inhibitor. See Fibrin, Fibrinolysis, TAFI.