progesterone receptor

(redirected from Receptors, progesterone)

progesterone receptor

[MIM*607311]
intracellular receptor for progesterone; often overexpressed in breast cancer.

progesterone receptor

A progesterone-binding protein complex found in the cytoplasm of certain cells in particular of the breast, which belongs to the nuclear receptor family. See Progesterone receptor assay. Cf Estrogen receptor.

pro·ges·ter·one re·cep·tor

(prō-jes'tĕr-ōn rĕ-sep'tŏr)
Intracellular receptor for progesterone; often overexpressed in breast cancer.
References in periodicals archive ?
Triple-negative breast cancer (TNBC) is a type of breast cancer characterized by breast cancer cells that do not express estrogen receptors, progesterone receptors, or large amounts of HER2/neu protein.
Triple positive, positive for estrogen receptors, progesterone receptors, and HER2
However, higher doses of the drug in addition to physiological androgen receptors, other receptors such as estrogen receptors, progesterone, mineralocorticoid and glucocorticoid negative feedback response to the occupation and lead to brain.
Immunohistochemical analysis of estrogen receptors, progesterone receptors, Ki-67 antigen, and human papillomavirus DNA in normal and neoplastic epithelium of the uterine cervix.
The trial involved 8,010 postmenopausal women with invasive breast cancer that was positive for estrogen receptors, progesterone receptors, or both.
5-6 years; a histologically confirmed primary breast cancer; a tumor positive for estrogen receptors, progesterone receptors, or both; discontinued tamoxifen therapy for less than 3 months before enrollment; and Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2 (range 0-5).
Sixteen formalin fixed, paraffin embedded breast cancer specimens from eleven patients in Guinea were obtained for the investigation of the suitability of standard laboratory methods for epidemiologic research: staining with hematoxylin and eosin (H&E), histochemical staining for estrogen receptors, progesterone receptors, and p53 proteins, and DNA extraction.
Triple negative breast cancer (TNBC) tumors do not express estrogen receptors, progesterone receptors, and low HER2.
0% in extraskeletal myxoid chondrosarcoma, a rare soft tissue sarcoma), but were frequently observed in other types, including triple-negative breast cancer (TNBC, a subtype of breast cancer that lacks estrogen receptors, progesterone receptors, or large amounts of HER2/neu protein; 70%), bladder cancer (73%), microsatellite instability high (MSI-H) colon cancer (77%), non-small cell lung cancer (NSCLC, 75%), endometrial cancer (86%), and ovarian cancer (93%).
Viewing slides digitally gives numerous advantages that glass slides do not provide; for example, tumors and areas suspicious for disease can be measured more precisely; images can be manipulated and utilized for consultation and teaching purposes; images can be viewed by more than 100 people simultaneously from anywhere in the world; and automated, quantifying algorithms for estrogen receptors, progesterone receptors, and HER2 have since been developed and FDA-cleared, reports Joon Yim, MD, director of digital pathology at Acupath Laboratories.
The study was conducted using clinical data with so-called "triple-negative" breast cancer, a form of the disease that is not responsive to therapies targeting estrogen receptors, progesterone receptors, or the HER2 receptor.

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