chemokine receptor

(redirected from Receptors, chemokine)

chemokine receptor

Abbreviation: CCR
Any of several protein receptors for chemokines that spans the cell membrane and links to intracellular G proteins. The cell-to-cell signaling and regulating effects of chemokines, e.g., on inflammation or hematopoiesis, are mediated through chemokine receptors, which can be blocked with specific antagonist drugs. CCR5 and CXCR4 are chemokine receptors that are also receptors for HIV. The virus uses these receptors to gain entry into T cells, macrophages, and other CD4+ cells.
See also: receptor

Chemokine receptor

A receptor on the surface of some types of immune cells that helps to mediate entry of HIV into the cell.
Mentioned in: AIDS