insulin receptor

(redirected from Receptor, insulin)

INSR

A gene on chromosome 19p13.3-p13.2 that encodes insulin receptor, the binding of insulin to which stimulates glucose uptake.

Molecular pathology
Defects of INSR cause Rabson-Mendenhall syndrome, leprechaunism and hyperinsulinaemic hypoglycaemia type 5.

insulin receptor

A heterodimeric membrane receptor composed of α and
β chains, which has tyrosine kinase activity after binding insulin; IR deficiency is a rare cause of DM and may be due to a gene rearrangement, causing a deletion in the tyrosine kinase domain, a point mutation with a loss of the ATP binding site or other genetic defect
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Muscular Insulin receptor, Insulin receptors phosphorylation, insulin receptor substrate-1, serine/thereonine kinase.
Key words: bisphenol A, diabetes, endocrine disruptors, estradiol, estrogen receptor, insulin, islet of Langerhans, nongenomic, xenoestrogens.
The majority of the genes with increased expression were involved in insulin signal transduction pathway including insulin, insulin receptor, insulin receptor substrate, PDX1, glucagon, glucagon receptor, GLP-1 receptor, neuroD and Glut4.

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