reactive lymphocyte

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atypical lymphocyte

An enlarged dysmorphic lymphocyte characterised by an often irregular monocyte-like nucleus that may stretch the length of the cell, with chromatin strands that parallel the length of the nucleus; nucleoli and azurophilic granules may be present. Atypical lymphocytes are seen in various non-neoplastic conditions, classically in infectious mononucleosis (<20% of circulating WBCs are atypical), toxoplasmosis, CMV infection and viral hepatitis.

ALs were formerly (and arbitrarily) grouped into three types, now of historic interest:
• Type I—Monocyoid or prolymphocytic kidney-shaped or lobulated nuclei, with densely homogeneous hypergranular chromatin, more similar to mature lymphocytes than plasma cells; cytoplasm is bubbly, eccentric and basophilic.
• Type II—Cytoplasmic radiations from the nucleus (“ballerina skirt” cells); cells have 1+ nucleoli; chromatin is less dense and cytoplasm is less foamy than type I, contains some azurophilic granules, is basophilic, and “scallops” around RBCs.
• Type III—Nuclei are coarse, span the cell’s breadth, have clumped red-to-purple chromatin with 1–4 nucleoli; the cytoplasm is abundant, basophilic, and “scallops” around adjacent RBCs. ALs have abundant cytoplasm, with basophilic condensations where they abut RBCs; mitochondria are large, numerous and scattered throughout the cytoplasm.

reactive lymphocyte

A lymphocyte that has become enlarged as a result of stimulation by antigens. Such a lymphocyte can be over 30 µm in diameter and of varying sizes and shapes.
See also: lymphocyte
References in periodicals archive ?
1 Viral meningitis Suspected LCM 2 Lymphocytic meningitis Suspected LCM 3 Lymphocytic meningitis Suspected LCM 4 Lymphocytic meningitis Suspected LCM 5 Tuberculosis meningitis Miscoded 6 Lyme encephalitis Miscoded 7 Lymphocele Miscoded 8 Lymphocytic cholitis Miscoded 9 Lymphocytic leukemia Miscoded 10 Lymphocytic leukemia Miscoded 11 Atypical lymphocytes Miscoded 12 Reactive lymphocytes Miscoded 13 Charcot foot anomaly Miscoded 14 Tuberculosis Miscoded * Diagnosis was the first listed or most clinically relevant written diagnosis from the medical record.
3] (neutrophils 55%, lymphocytes 35%, monocytes 7%, reactive lymphocytes and Downey cells), hemoglobin 12 g/dL, hematocrit 38%, and normal platelet count.
Abnormal cells, band forms, and reactive lymphocytes are easily detected and numbers estimated when the slide is scanned by an expert.
We have one that reads: "Automated differentials may not always detect band forms, reactive lymphocytes, or abnormal cells.
The development of the immune system, including the development of the repertoire of reactive lymphocytes that will exist in postnatal life, begins prenatally.
14] The specimens were cellular with follicular cells arranged in 3-dimensional groups, papillary fragments, and single cells in the background of numerous reactive lymphocytes (Figure 1, A-C).
1,2,18-20] However, the tumors, especially papillary carcinoma arising in the background of lymphocytic thyroiditis, usually show 2 cell populations in cytology samples[13,18,19]; namely, tumor cells with nuclear features of papillary carcinoma and a background population of Hurthle cells intermixed with small and large reactive lymphocytes.
FC analysis plays an important role in distinguishing reactive lymphocytes from malignant cells in CSF, since cytology can not provide information about pattern of growth and effacement of the architecture.
Comparison of cytograms from hematology systems with the those generated by the flow cytometer assists in assuring that larger reactive lymphocytes, particularly those with granules, are included in the correct analytic gate.
1) Transfer of GAD reactive lymphocytes between animals transfers
If any blasts, abnormal lymphoid cells, other abnormal or unclassifiable cells, [greater than]1 nRBC, [greater than]5% immature granulocytes (metamyelocytes, myelocytes, or promyelocytes), or [greater than]5% reactive lymphocytes are seen, a manual differential must be performed.

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