5 mg bid for 1 month; then 6 mg bid Galantamine Razadyne
4 mg bid for Nausea, vomiting, 4 weeks; 8 diarrhea, fatigue, mg bid for 4 somnolence, weeks; then Bradycardia 12 mg bid N-methyl-D-aspartate antagonist Memantine Namenda 5 mg qd for Agitation 1 week; 5 mg bid for 1 week; 10 mg am and 5 mg pm for 1 week; then 10 mg bid Generic Name Precautions Advantages Cholinesterase inhibitors Donepezil Asthma/seizures Once daily dosing Rivastigmine Concomitant use of Butyl, NSAIDs; esophagitis, cholinesterase asthma, seizures.
RxAmerica and Medco no longer will require physicians to go through the prior authorization process before they prescribe Aricept (donepezil), Exelon (rivastigmine), Razadyne
(galantamine), and Namenda (memantine) for Medicare Part D beneficiaries over age 65.
(formerly named Reminyl), Aricept, and Exelon may slow the progression of dementia and are especially helpful in early treatment of the disease.
Applicants for the trial must be in good genereal health and diagnosed with early-stage AD, between 55 and 80 years of age, live at home, have been on a stable dose for at least two months of an FDA-approved drug for AD (Aricept, Razadyne
, or Exelon), and have a reliable spouse, relative, or caregiver who agrees to cooperate with the study.
Galantamine Tablets USP, Barr Laboratories Razadyne
Galantamine innovator: Janssen (Razadyne
ER, Reminyl, Reminyl XL)
Drugs currently in use for AD treatment (such as Aricept, Razadyne
, and Exelon) are associated with temporary moderate improvements in memory, but do not halt the progress of the disease.
In other news, Watson Pharmaceuticals has been given regulatory clearance for generic Razadyne
Reminyl, indicated for mild to moderate Alzheimer's disease, has been officially renamed Razadyne
Three major primary medications on the market for Alzheimer disease - Aricept, Exelon, and Razadyne
are AChE inhibitors, and the fourth medication, Namenda, is a NMDAr antagonist.
has received final approval from the Food and Drug Administration to manufacture and market a genetic version of Ortho McNeil Janssen's Razadyne
(galantamine hydrobromide), 4 mg, 8 mg and 12 mg tablets.
Aricept, Exelon, and Razadyne
belong to the same class of cholinesterase inhibitors.