Professionals can then administer monthly boosters of the vaccine to generate an immune response against mutant RAS protein
2, ras proteins
were detected at high level after addition of Dex, which was used as an inducer of mutated human N-ras oncogene.
Upon detecting functional similarities between a yeast sex hormone and the yeast form of ras, the researchers, hypothesized that farnesyl provides the missing dab of grease at the tail end of the ras protein
Products in the GI-4000 series target the mutated Ras protein
which occurs in 75-90% of pancreatic cancers, 35-45% of colorectal cancers, and 30-35% of non-small cell lung cancers.
Raf has been shown to facilitate the Ras protein
function, an oncogene known to be involved in the initiation and progression of some human tumors.
They found that the vaccinated mice generated CTL responses specific for the ras protein
against which they were immunized, protecting them from challenge with tumors expressing that ras protein
Recent research developments and advances in technology have created promising opportunities to attack RAS proteins
and now is a critical time to re-energize our efforts in this area," said Dr.
Scientists turned to cancer drug selumetinib, which has been designed for other cancers to tackle Ras proteins
Mutations in Ras proteins
can result in excessive signals for cells to proliferate and cause them to ignore cues for programmed cell death, leading to unchecked growth and tumor formation.
Inhibiting this enzyme causes a reduction in the endogenous production of mevalonate, which in turn triggers a series of reactions resulting in decreased biologic activity of Ras proteins
and other oncogenes.
In her dissertation, Anna-Karin Sjogren studied how mutations (activation) of RAS proteins
contribute to the formation of many forms of tumors, such as cancer of the large intestine, lungs, blood and pancreas.