Added to patient-derived cells in culture, rapamycin
enabled the development of more Purkinje precursor cells, improved the functioning of their synapses and increased their tendency to fire.
Among the mouse models that were given rapamycin
and the gene therapy, 71 percent and 80 percent went into near-complete remission after having hind-limb paralysis.
The mammalian target of rapamycin
(mTOR) signaling pathway regulates cell metabolism, survival, growth, and proliferation.
is an immunosuppressant used to coat coronary stents and prevent rejection of transplanted organs.
Matt Kaeberlein, PhD (professor of pathology, University of Washington, Seattle) wants to validate rapamycin
as an anti-aging drug.
The mice given rapamycin
lived 25 percent longer than those that weren't given the drug.
To study the role of mTOR signaling pathway in BMECs, we examined the effects of rapamycin
, a specific inhibitor of mTORC1, on ELOVL1 expression and DHA synthesis.
The JAK2 and STAT3 mRNA expression levels in the control, HMGB1, AG490 (JAK2 inhibitor), and rapamycin
(STAT3 inhibitor) groups at 10, 30, 60, and 120 minutes were detected using reverse transcription polymerase chain reaction (RT-PCR), and the results are shown in Figures 2 and 3.
In their previous work, investigators at the Tohoku University Graduate School of Medicine in Japan found that rapamycin
treatment can reduce nerve damage and locomotor impairment after SCI.
The sirolimus/FKBP-12 complex binds to and inhibits activation of the regulatory kinase, the mammalian target of rapamycin
(mTOR), thus inhibiting the progression from [G.
is an immune suppressant that also has anticancer effects.
(Sirolimus) has been used for the treatment of some refractory cases of OLP.