However Miguel et al (15) compared rapacuronium and succinylcholine and observed that there was no clinically significant increase in the heart rate in succinylcholine group like in our study.
Rafel Miguel, Thomas Witkowski et al: Evaluation of neuromuscular and cardiovascular effects of two doses of rapacuronium versus mivacurium and succinylcholine.
Haemodynamic effects of rapacuronium
in adults with coronary artery or valvular disease.
Org 9487, rapacuronium (Raplon) generated considerable excitement at the time of the phase III clinical trials in 1999.
Bronchospasm proved to be the biggest problem with rapacuronium.
Rapacuronium (Org 9487): do we have a replacement for succinylcholine?
A mechanism for rapacuronium
induced bronchospasm, M2muscuronic receptor antagonism.
Sloan PA and Rasul M have reported a prolonged neuromuscular block with non depolarizing muscle relaxant rapacuronium in the presence of clindamycin & magnesium (24) Hypermagnesemia enhances sensitivity of all NDMR.
Sloan PA, Rasul M, Prolongation of rapacuronium neuromuscular blockade by Clindamycin & magnesium Anesth Analg 2002; 94 (1): 123-4.
They are Alcuronium, Atracurium (atrilix, tracrium, acuran), cisatracurium, daxacurium, mivacurium, pancurium (pavilon), vecuronium (norcurium), pipecuronium, rocuronium (esmeron) and rapacuroniums