randomized controlled trial

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ran·dom·i·zed con·trolled tri·al (RCT),

an epidemiologic experiment in which subjects in a population are allocated randomly into groups, called "experimental" or "study" and "control" groups to receive or not receive an experimental therapeutic or preventive regimen, procedure, maneuver, or intervention.

ran·dom·i·zed con·trolled tri·al

(RCT) (ran'dŏm-īzd kŏn-trōld trī'ăl)
A type of experiment that randomly assigns subjects to various interventions, including a control group, in order to minimize the risk of bias.
See also: control group

randomized controlled trial

Abbreviation: RCT
An experimental study to assess the effects of a particular variable, e.g., a drug or treatment, in which subjects are assigned randomly to an experimental, placebo, or control group. The experimental group receives the drug or procedure; the placebo group's medication is disguised to resemble the drug being investigated. The control group receives nothing. Members of each group are prevented from knowing whether they are receiving active therapy. The researchers gathering the data are also typically blinded to group assignment.

CAUTION!

Although RCTs are an essential element in proving clinical relationships (such as between the use of a new drug and the safe cure of a disease), most RCTs do not enroll enough patients for a long enough time to detect rare events.
See also: trial

trial, randomized controlled (RCT) 

An experimental design used for testing the effectiveness of a new medication or a new therapeutic procedure. Individuals are assigned randomly to a treatment group (experimental therapy) and a control group (placebo or standard therapy) and the outcomes are compared. The trial is strengthened by 'blinding' or masking (single-blind, double-blind or triple-blind study) and cross-over design. RCT is the most accepted scientific method of determining the benefit of a drug or a therapeutic procedure. It represents the best evidence available, which is integrated into the final decision about the management of a condition by healthcare practitioners in what is called evidence-based healthcare. Syn. randomized clinical trial. See sampling; significance; study.
References in periodicals archive ?
Concern about cardiovascular events associated with the use of varenicline were sparked by findings from a 2001 meta-analysis of 11 randomized controlled trials that showed the drug raised the risk of cardiovascular events in smokers with existing heart disease.
All published randomized controlled trials after 1995 with sample size of over 100 and which were printed in English language and had compared the effectiveness of laparoscopic inguinal hernia repair with open mesh inguinal hernia repair were eligible for inclusion.
A new paper published in the International Journal of Epidemiology says that randomized controlled trials (the gold standard method of evaluation) show that few currently available screening tests for major diseases where death is a common outcome have documented reductions in disease-specific mortality.
Randomized controlled trials (RCTs) are considered the gold standard for evaluation of healthcare interventions.
Randomized controlled trials comparing probiotics with controls in inflammatory bowel disease and data related to remission/response rates, relapse rates, and adverse events were included in this meta-analysis.
undertook a meta-analysis of randomized controlled trials of calcium supplements with or without vitamin D.
RIGOROUS CONTROL CONDITIONS DIMINISH TREATMENT EFFECTS IN WEIGHT LOSS RANDOMIZED CONTROLLED TRIALS.
The study took place in the context of a high school randomized controlled trial (Maryland Safe and Supportive Schools [MDS3]--58 high school randomized controlled trials funded by the U.
Acupuncture for chronic low back pain in long-term follow-up: a meta-analysis of 13 randomized controlled trials.
De qi is a combination of sensations stimulated by manipulation of acupuncture needles - soreness, tingling, coolness, warmth and others radiating at the insertion points - but has not been validated by randomized controlled trials.
The study, "Misrepresentation of Randomized Controlled Trials in Press Releases and News Coverage: A Cohort Study," by Yavchitz et al.
We conducted a systematic review of randomized controlled trials published between 1996 and 2011 examining the relation between algal oil supplementation and cardiovascular disease risk factors and performed a meta-analysis of the association between algal oil DHA supplementation and changes in the concentrations of TG, LDL-cholesterol (LDL-C), and HDL-cholesterol (HDL-C).

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