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randomized controlled trial

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
trial, randomized controlled (RCT) 
An experimental design used for testing the effectiveness of a new medication or a new therapeutic procedure. Individuals are assigned randomly to a treatment group (experimental therapy) and a control group (placebo or standard therapy) and the outcomes are compared. The trial is strengthened by 'blinding' or masking (single-blind, double-blind or triple-blind study) and cross-over design. RCT is the most accepted scientific method of determining the benefit of a drug or a therapeutic procedure. It represents the best evidence available, which is integrated into the final decision about the management of a condition by healthcare practitioners in what is called evidence-based healthcare. Syn. randomized clinical trial. See sampling; significance; study.


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The new insights come from a randomized controlled trial that tested the impact of twice-weekly weight lifting for 12 months on survivors' health and emotional status.
Duncan Young from John Radcliffe Hospital in Oxford and colleagues carried out the first randomized controlled trial to compare collaborative requesting with routine testing.
Summary of: Kroenke K, Bair MJ, Damush TM, Wu J, Hoke S, Sutherland J, Tu W (2009) Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain; a randomized controlled trial.
 
 
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