randomized controlled trial

(redirected from Randomized control trials)

ran·dom·i·zed con·trolled tri·al (RCT),

an epidemiologic experiment in which subjects in a population are allocated randomly into groups, called "experimental" or "study" and "control" groups to receive or not receive an experimental therapeutic or preventive regimen, procedure, maneuver, or intervention.

ran·dom·i·zed con·trolled tri·al

(RCT) (ran'dŏm-īzd kŏn-trōld trī'ăl)
A type of experiment that randomly assigns subjects to various interventions, including a control group, in order to minimize the risk of bias.
See also: control group

randomized controlled trial

Abbreviation: RCT
An experimental study to assess the effects of a particular variable, e.g., a drug or treatment, in which subjects are assigned randomly to an experimental, placebo, or control group. The experimental group receives the drug or procedure; the placebo group's medication is disguised to resemble the drug being investigated. The control group receives nothing. Members of each group are prevented from knowing whether they are receiving active therapy. The researchers gathering the data are also typically blinded to group assignment.

CAUTION!

Although RCTs are an essential element in proving clinical relationships (such as between the use of a new drug and the safe cure of a disease), most RCTs do not enroll enough patients for a long enough time to detect rare events.
See also: trial

trial, randomized controlled (RCT) 

An experimental design used for testing the effectiveness of a new medication or a new therapeutic procedure. Individuals are assigned randomly to a treatment group (experimental therapy) and a control group (placebo or standard therapy) and the outcomes are compared. The trial is strengthened by 'blinding' or masking (single-blind, double-blind or triple-blind study) and cross-over design. RCT is the most accepted scientific method of determining the benefit of a drug or a therapeutic procedure. It represents the best evidence available, which is integrated into the final decision about the management of a condition by healthcare practitioners in what is called evidence-based healthcare. Syn. randomized clinical trial. See sampling; significance; study.
References in periodicals archive ?
Previously, Michael has worked on Randomized Control Trials (RCTs) of Information & Communication Technology Development Innovations in different countries.
Educators and evaluators attending the American Evaluation Association's Annual Conference this week will have the opportunity to learn how the research community, textbook publishers, and schools are now effectively collaborating to implement No Child Left Behind's mandated Randomized Control Trials to demonstrate the efficacy of curriculum materials.
The un-schooled might consider Randomized Control Trials somewhat of an oxymoron.
Pearson Education's Director of Academic Research, Marcy Baughman, said, "Compliance with the Department of Education's What Works Clearinghouse demands that more Randomized Control Trials (RCTs) in curriculum evaluation be conducted; however, few evaluators are discussing ways to prepare, launch, and successfully implement an RCT in educational settings.
95) gathers evidence on placebos, randomized control trials, and more to conclude alternative therapies could indeed provide new paths to help chronic disease sufferers.
They are the output of collective reviews of state of the art references in the field with a focus on randomized control trials.
The pooled analysis based on the two largest multicenter randomized control trials (RCTs) evaluating the safety and efficacy of Aranesp treatment in 475 patients with symptomatic heart failure and anemia, LVEF less than or equal to 40 percent and Hb levels of 9.

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