radioimmunotherapy


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radioimmunotherapy

 [ra″de-o-im-mu″no-ther´ah-pe]
use of radionuclides to deliver monoclonal antibodies to targeted cancer cells.

radioimmunotherapy

[ra′dē·ōim-mu′no-ther′ah-pe]
use of radionuclides to deliver monoclonal antibodies to targeted cancer cells.

radioimmunotherapy

Immunology The use of radio-labeled–monoclonal antibodies that recognize specific antigens, and therefore concentrate in a particular tissue to treat disease Toxicity Myelosuppression, nausea, infections, cardiopulmonary toxicity

radioimmunotherapy

(rā′dē-ō-ĭm″ū-nō-thĕr′ă-pē)
The use of radioactively labeled monoclonal antibodies to treat malignancies, e.g., breast cancers, non-Hodgkin's lymphoma, and prostate cancer. The monoclonal antibodies selectively bind with antigens on the tumor cells and deliver a dose of cell-killing radiation directly to those cells.
References in periodicals archive ?
The first poster session features MVT-1075, the Company's novel fully human antibody-based radioimmunotherapy currently being evaluated in clinical development for the treatment of pancreatic cancer and other CA19-9 positive malignancies.
Additionally, patient dosing has commenced for its lead development program in Phase 1 clinical study of the company's radioimmunotherapy product MVT-1075.
Net proceeds may be used by the company to fund continuing clinical development of its HuMab 5B1 antibody designated MVT-5873 in combination with gemcitabine and nab-paclitaxal in first line therapy for the treatment of pancreatic cancer, to support the continued clinical development of its radioimmunotherapy product designated as MVT-1075 for the treatment of locally advanced or metastatic pancreatic cancer patients as well as for general corporate purposes.
The novel radioimmunotherapy approach could be a source of new hope for patients with lymph node, prostate or breast cancer.
The first section covers malignant hematology and hematopoietic cell transplantation, including acute lymphoblastic and myeloid leukemia in adults, myelodysplastic syndromes and related disorders, myeloproliferatve neoplasms, chronic lymphocytic and other leukemias, Hodgkin and non-Hodgkin's lymphoma, plasma cell neoplasms and related disorders, and special issues in hematology and hematopoietic call transplantation, such as PET (positron emission tomography) scans in lymphomas, radioimmunotherapy, radiation oncology consultation, donor and graft selection, prevention and treatment of relapse, and acute and chronic graft-versus-host disease.
Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa.
Washington, Dec 04 ( ANI ): Researchers have used radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)-infected cells in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV infection.
Dr Ekaterina Dadachova and colleagues from Albert Einstein College of Medicine of the Yeshiva University in the US found that radioimmunotherapy (RIT) was successful in destroying the HIV-infected cells without affecting or causing any harm to the healthy cells.
We have worked on over 65 ADC candidates and over 30 different ADC drug linkers to date and also have experience with PEGylation, chelating conjugates for radioimmunotherapy and protein toxin conjugates.
Created by the Company's proprietary DOCK-AND-LOCK method, the bispecific antibody is currently in a number of clinical trials for pretargeted immunoPET imaging and radioimmunotherapy of patients with CEA-expressing cancers.
Extremely targeted cancer- treatment - In 2011, Areva Med, working with researchers from the University of Alabama, got the green light from the US Food and Drug Administration to start a phase one clinical trial with Pb 212, using radioimmunotherapy.
It contains more than 2,000 questions and answers, updated chapters, and a new chapter of radionuclide therapy with information on radioimmunotherapy of lymphoma and Y-90 SIRT of hepatitic malignancies.