Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense
It's been a decade since the pivotal DMIST study determined that digital mammography delivers greater breast cancer detection accuracy than film-screen mammography in women under age 50 and those with radiographically dense
Although this has shown no significant difference in diagnostic accuracy between FFDM and SFM , the DMIST did show that digital mammography is more accurate in women under the age of 50 years, women with radiographically dense
breasts, and premenopausal and perimenopausal women [15,16].
While fat appears dark on a mammogram, other areas of the breast are radiographically dense
and look light, which is referred to as mammographic density.
1) Radiographically dense
breasts also can present a diagnostic imaging challenge for the early detection of breast carcinoma because of the following factors (2):
The overlap of normal radiographically dense
structures can obscure existing neoplastic tissue and also can create the illusion of a lesion where no true lesion is present.
A lot of "structured noise" is created by the overlap of normal radiographically dense
Mammograms in women with radiographically dense
breasts are more difficult to interpret, and may not reveal a cancer that is present.
This blinded, prospective, multi-center study (Kelly K, Dean J, et al, Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense
breasts, Eur Radiol (2010) 20: 734-742) was designed to compare the screening performance of mammography alone with that of mammography plus SonoCine.
Breast cancer detection: using automated whole breast ultrasound and mammography in radiographically dense
Kelly KM, Dean J, Comulada WS, Sung-Jae L: "Breast Cancer Detection Using Automated Whole Breast Ultrasound and Mammography in Radiographically Dense
Breasts" European Radiology (2010) 20: 734-742