RUNX3

RUNX3

A gene on chromosome 1p36 that encodes a member of the runt domain-containing family of transcription factors. A heterodimer of RUNX3 and a beta subunit form a complex found in a number of enhancers and promoters, and together either activate or suppress transcription. RUNX3 is a tumour suppressor which also interacts with other transcription factors. 

Molecular pathology
RUNX3 deletion or transcriptional silence may be associated with cancer.
References in periodicals archive ?
The N-terminal CagA region binds to the gastric tumor suppressor RUNX3 to promote proteasome-mediated degradation of RUNX3 by recruiting an unidentified E3 ubiquitin ligase.
RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors.
At least four loci can serve as sensitive and specific markers for CIMP-high, these include RUNX3, CACNA1G, IGF2, and MLH1 [101].
New study also identified a potential way to increase effectiveness of cancer therapy Scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have discovered that modifications to a protein called RUNX3 may promote cancer progression.
Algunos de los genes estudiados en el contexto de hipermetilacion de sus promotores en cancer de pulmon incluyen: CDKNA/P16INK4a, RASSF1, MGMT, APC, DAPK, FHIT, CDH13, RAR [beta], SHOX2, RUNX3, CDH1, TSCL1, ASC/TMS1, DAL1, PTEN, GSTP1.
RUNX3 encodes a member of the runt domain-containing family of transcription factors, which might have important functions in innate and adaptive immune cell types and might be associated with several inflammatory-related diseases (Lotem et al.
Boonla, "Oxidative stress induces hypomethylation of LINE-1 and hypermethylation of the RUNX3 promoter in a bladder cancer cell line," Asian Pacific Journal of Cancer Prevention, vol.
61) Other genes that have been found to be hypermethylated in multiple studies of smoking-related cancers include TIMP3, FHIT, RUNX3, MLH1, and CHFR.
Overexpression of RUNX3 inhibits malignant behaviour of Eca109 cells in vitro and vivo.
The Transcription Factor GATA3 actively represses RUNX3 protein-regulated production of interferon-[gamma].
Analysisof PPARGC1B RUNX3 and TBKBP1 polymorphisms inChinese Han patients with ankylosing spondylitis: a case-control study.
De otro lado, en los ultimos anos se han propuesto estudios de metilacion en CCR con multiples genes candidatos, entre ellos p16, MGMT, RASSF2AA, APC, RUNX3, MIN e IGF2 (56).