RUNX2


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Related to RUNX2: RUNX1

RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
References in periodicals archive ?
Phosphorus is mediated mainly in SMCs by PiT1, which causes VSMCs to lose expression of the SM contractile proteins a-SMA and SM22 and instead express the bone markers Runx2, osteocalcin, and ALP, thereby causing vascular calcification.
The potential for osteoblast/cementoblast differentiation was further confirmed by qRT-PCR analysis, showing an increased expression of a key osteoblast transcription factor, RUNX2, and two osteoblast-specific early/late differentiation transcripts (ALP and OCN, respectively) in osteogenically-induced cells compared to non-induced (Figure 3C).
El gen RUNX2 se expresa desde etapas tempranas del desarrollo embrionario [9] y su principal funcion es encargarse de huesos y cartilagos con una fuerte expresion de caracter osteogenico y odontogenico [10].
Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2," Bone, vol.
Moreover, Osterix is an osteoblast-specific transcription factor required for osteoblast differentiation, acts as downstream of Runx2 to induce mature osteoblasts, and attenuates osteoblast proliferation via inhibition of Wnt pathway owing to feedback during osteoblastic differentiation and bone formation [36].
These growth factors have the role of nuclear transcription factors present in chondrocytes and these latter are found in the Sox and Runx2 family members, which are substantial in the initiation of embryonic growth of the condyle.
Use of RUNX2 Expression to Identify Osteogenic Progenitor Cells Derived from Human Embryonic Stem Cells"; Stem Cell Reports, 2015; 4 (2): 190 DOI: 10.
Transcriptional corepressor TLE1 functions with Runx2 in epigenetic repression of ribosomal RNA genes.
Genes that are critical transcription factors and regulators of osteogenesis such as Runx2, osterix (Osx) and LIM domain mineralization protein (LMP) may hold promise in periodontal tissue engineering, especially in alveolar bone augmentation.
The list includes NPPS (nucleotide pyrophosphatase)/ENNP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1), (10) TGFB1 (transforming growth factor [beta]1), (23) ESR (estrogen receptor), (24) IL-1[beta], (24) VDR (vitamin D receptor), (25) BMP2, (26) RUNX2, (27) IL-15RA, (28) BMP9, (29) and TGFB3.
Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.