RUNX2


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Related to RUNX2: RUNX1

RUNX2

A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression.

Molecular pathology
RUNX2 mutations cause cleidocranial dysplasia, a bone development disorder.
References in periodicals archive ?
We further demonstrated that CLT suppressed MMPs expression via down-regulation of the transcriptional activity of Runx2 (Wang et al.
3]-inhibited Runx2 protein expression (Figure 3B), ALP activity (Figure 3C), osteoblast mineralization (Figure 3D), and Bmp2 (Figure 4A) and osteocalcin (Figure 4B) mRNA expression during osteoblast differentiation.
We also describe anti-metastatic effects of ISTA (3) in breast cancer cells via induction of EMT inhibition, which may be associated with inhibition of Runx2 transcriptional activity.
2007) using the following antibodies: polyclonal rabbit Runx2, collagen 1 (Col1), or [beta]-actin, all from Abcam (Cambridge, MA); peroxisome proliferator-activated receptor-[gamma] (PPAR[gamma]), CCAAT/enhancer-binding proteins [beta] (C/EBP[beta]) or [alpha] (C/EBP[alpha]), all from Santa Cruz Biotechnology (Santa Cruz, CA); monoclonal mouse [beta]-catenin (Santa Cruz Biotechnology); or polyclonal goat Scl and Dickkopf1 (DKK1), both from R&D Systems.
During differentiation, DPHD promoted early expression of osteoblast transcription factors, RUNX2 and osterix.
Further, both the flavonoids were also found to increase the expression of some of the prominent markers for differentiation of osteoblast like osteopontin, osterix, RunX2, osteoprotegerin and osteocalcin.
mirifica extract and puerarin significantly increased the mRNA expression of alkaline phosphatase (ALP) and osteoprotegerin, but not Runx2, osterix or osteocalcin.
Additionally, inhibition of p38 abolished the stimulatory effect of NBIF on the expression of Runx2 and Osx.
Both neoeriocitrin and naringin exhibited the best effect on proliferation and osteogenic differentiation at concentration of 2 [micro]xg/ml Neoeriocitrin more significantly improved proliferation and alkaline phosphatase (ALP) activity as well as up-regulated Runx2, COLI and OCN expression by 56%, 37% and 14% respectively than naringin.
In this study, we demonstrate that in vitro icariin is a bone anabolic agent that may exert its osteogenic effects through the induction of BMP-2 and NO synthesis, subsequently regulating Cbfal/ Runx2, OPG, and RANKL gene expressions.