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RU-486 |
Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia, Hutchinson | 0.03 sec. |
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RU-486 mifepristone. RU-486. See mifepristone. mifepristone (RU-486) Warning - Hazardous drug! Mifegyne (UK), Mifeprex Pharmacologic class: Synthetic steroid Therapeutic class: Antiprogestational agent, abortifacient Pregnancy risk category NR FDA Boxed Warning• Rare cases of serious and sometimes fatal infections and bleeding have followed spontaneous, surgical, and medical abortions, including after mifepristone use. Before starting drug, inform patient of risk of these serious events and discuss medication guide and patient agreement. Ensure that patient knows whom to call and what to do, including going to emergency department (ED) if none of provided contacts are reachable; if she experiences sustained fever, severe abdominal pain, prolonged heavy bleeding, or syncope; or if she has abdominal pain or discomfort or general malaise (including weakness, nausea, vomiting, or diarrhea) more than 24 hours after taking drug. ActionAntagonizes progesterone receptor sites, inhibiting activity of endogenous and exogenous progesterone and stimulating uterine contractions, which causes fetus to separate from placental wall AvailabilityTablets: 200 mg ⊘Indications and dosages ➣ Termination of intrauterine pregnancy through day 49 of pregnancy Adults: On day 1, mifepristone 600 mg P.O. as a single dose. On day 3, misoprostol 400 mcg P.O. (unless abortion has been confirmed). Contraindications• Hypersensitivity to drug, misoprostol, or other prostaglandins PrecautionsUse cautiously in: Administration• Before giving, make sure patient doesn't have an IUD in place.
Adverse reactionsCNS: dizziness, fainting, headache, weakness, fatigue, insomnia, asthenia, anxiety, syncope, rigors EENT: sinusitis GI: nausea, vomiting, diarrhea, abdominal cramping, dyspepsia GU: vaginitis, leukorrhea, uterine cramping, pelvic pain, uterine hemorrhage Hematologic: anemia Musculoskeletal: leg pain, back pain Skin: fever Other: viral infections InteractionsDrug-drug. Carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampin: decreased mifepristone blood level and effects Drugs metabolized by CYP450-3A4: decreased mifepristone metabolism and increased effects Erythromycin, itraconazole, ketoconazole: inhibited mifepristone metabolism and increased blood level Drug-diagnostic tests. Hematocrit, hemoglobin: decreased values Red blood cells: decreased count Drug-food. Grapefruit juice: decreased mifepristone blood level and effects Patient monitoring• Assess vital signs, breath sounds, and bowel sounds. Patient teaching• After administration, tell patient she'll need to return in 48 hours for a prostaglandin drug or to verify pregnancy termination. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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