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respiratory syncytial virus immune globulin
(redirected from RSV-IGIV)

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respiratory syncytial virus immune globulin (RSV-IGIV),
an immune serum.
indications It is used in children less than 2 years of age with bronchopulmonary dysplasia or in those born prematurely to prevent serious lower respiratory tract infection caused by respiratory syncytial virus.
contraindications Factors that prohibit its use are hypersensitivity to this drug or to other human immunoglobulin preparations and IgA deficiency.
adverse effects Life-threatening effects are respiratory distress, hypoxia, anaphylaxis, and angioneurotic edema. Other adverse effects are tachypnea, rales, wheezing, fever, hypertension, tachycardia, fluid overload, diarrhea, gastroenteritis, vomiting, rash, overdose effect, and inflammation at the injection site.


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Some concerns that restrict the use of RSV-IGIV include (1) monthly IV infusions lasting several hours each, (2) increased fluid volume and protein loads necessitating occasional use of diuretics, (3) theoretical concerns for transmission of blood-borne pathogens, and (4) the potential for polyclonal immunoglobulin interference with the immune response to vaccination.
Respiratory syncytial virus infection and the primary care physician by Barnett, David W. / Southern Medical Journal
 
 
 
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