spermatogenic failure type 4

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spermatogenic failure type 4

An infertility disorder (OMIM:270960) clinically characterised by azoospermia and histologically characterised by spermatogenic arrest of primary spermatocytes at the pachytene stage.

Molecular pathology
Defects of SYCP3, which encodes a structural protein involved in synapsis, recombination and segregation of chromosomes during meiosis, cause spermatogenic failure type 4.