HDAC3

(redirected from RPD3-2)

HDAC3

A gene on chromosome 5q31 that encodes histone deacetylase 3; it belongs to the histone deacetylase/acuc/apha family, which represses transcription when tethered to a promoter and may regulate transcription by binding with the zinc-finger transcription factor YY1. HDAC3 downregulates p53 activity and thus modulates cell growth and apoptosis; it may be a tumour suppressor gene.