ROR1

ROR1

A gene on chromosome 1p32-p31 that encodes a tyrosine kinase belonging to the ROR subfamily of cell surface receptors, which modulates neurite growth in the CNS; its exact role is not known.
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References in periodicals archive ?
Cytoskeleton network and cellular migration modulated by nuclear localized receptor tyrosine kinase ROR1.
The only other member of the family that has been identified is ROR1, and this research was done to determine what role ROR1 might play in the progression of melanoma.
The researchers were able to determine that ROR1 inhibited the invasion of melanoma cells, and this receptor was targeted for degradation by Wnt5A and ROR2.
The scientists say that molecular signaling from Wnt5a - working in tandem with its co-receptors ROR1 and ROR2 in the uterus - causes uterine implantation chambers (crypts) in mice to form at regular intervals.