ROCK2

ROCK2

A gene on chromosome 2p24 that encodes a protein kinase which is a key regulator of actin cytoskeleton and cell polarity. It regulates smooth muscle contraction, actin cytoskeleton organisation, stress-fibre and focal adhesion formation, and neurite retraction, as well as cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, DPYSL2, EP300, EZR, IRF4, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A, SORL1 and VIM. It downregulates VEGF-induced angiogenesis.
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The core genes up-regulated in the pathways include TLR5, ROCK2, CD14, and YWHAZ, a gene encoding a member of the 14-3-3 family of proteins reported to interact with insulin receptor substrate-1 and thereby regulating insulin signaling.
The National Heart, Lung and Blood Institute has awarded the $206,302 grant to Worcester State for research into the role of a protein called ROCK2, which gets produced in cells lining the walls of blood vessels.
Bryan said he intends to involve Worcester State students in the ROCK2 research project, as he has done on other projects to give the students scientific experience that goes beyond their classroom work.
Novel ROCK2 Inhibitor Data Suggests Potential Activity in Unmet Medical Needs in Cancer, Autoimmune Diseases
In mid-2016, Lycera expects to initiate clinical studies for its lead immune-oncology product candidate, an agonist of RORgamma, as well as an anti-fibrotic agent, a highly selective ROCK2 (rho-associated kinase II) inhibitor.
This program is focused on developing ROCK2 selective compounds for inflammatory and fibrotic disease and a regulatory submission is planned for the end of 2006.