RNase P


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RNase P

an enzyme catalyzing the endonucleolytic cleavage tRNA precursors removing 5' extra nucleotide.

RNase P

(ahr-en-as')
An enzyme catalyzing the endonucleolytic cleavage tRNA precursors to yield 5'-phosphomonoesters.
References in periodicals archive ?
The qPCR included primers and probe for an attenuated amplification of the RNase P gene RPPH1.
Regression curves for each of the TREC and RNase P calibrators (Fig.
RealTime PCR systems TegMan RNASE P 96-WELL m2000rt Instrument Verification Plate
Similar to the ribosome, bacterial RNase P is a large catalytic ribonucleoprotein enzyme essential to bacterial survival, making it an ideal target for the development of drugs.
RNase P is an excellent RNA-based target, which is not exploited by existing antibiotics.
The Company's technologies utilize either External Guide Sequences (EGS) oligozymes - which inactivate targeted messenger RNA (mRNA) through use of cellular enzyme RNase P - or RILON(TM) oligozymes, which inactivate targeted mRNA directly.
Once the EGS molecules attach to their target, they cause a cellular enzyme called RNase P to destroy the mRNA to which they are bound; the EGS molecules are then freed to repeat the process.
Goldberg, in a talk entitled "Harnessing the Ribozyme RNase P to Develop Therapeutics," discussed several key advances in the Company's research.
EGSs are not ribozymes, but short oligonucleotides that redirect the activity of RNase P to target and destroy disease-causing RNA before they can be used to create disease-causing proteins.
Cashmore and his colleagues in plant cell research should enable us to gain valuable information about the effects of EGSs and their interaction with the RNase P enzyme in plant systems," said Dr.
External Guide Sequences (EGSs) are small oligonucleotides that can be designed to bind to disease-causing RNA, resulting in its inactivation through the cutting activity of RNase P, an enzyme present in all cells.
EGSs are not ribozymes but short oligonucleotides that redirect the activity of the ribozyme RNase P, an enzyme found in every living cell, to target disease-causing RNAs.