RNA splicing


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splic·ing

(splīs'ing),
1. Attachment of one DNA molecule to another. Synonym(s): gene splicing
2. Removal of introns from mRNA precursors and the reattachment or annealing of exons. Synonym(s): RNA splicing
3. Posttranslational modification of a protein involving two proteolytic enzymes and one ligation; results in the removal of an internal sequence of amino acyl residues.

RNA splicing

(in molecular genetics) the process by which base pairs that interrupt the continuity of genetic information in deoxyribonucleic acid are removed from the precursors of messenger ribonucleic acid.

splic·ing

(splīs'ing)
1. Attachment of one DNA molecule to another.
Synonym(s): gene splicing.
2. Removal of introns from mRNA precursors and the reattachment or annealing of exons.
Synonym(s): RNA splicing.

splic·ing

(splīs'ing)
1. Attachment of one DNA molecule to another.
Synonym(s): gene splicing.
2. Removal of introns from mRNA precursors and the reattachment or annealing of exons.
Synonym(s): RNA splicing.

RNA splicing,

n the process by which base pairs that interrupt the continuity of genetic information in deoxyribonucleic acid are removed from the precursors of messenger ribonucleic acid.
References in periodicals archive ?
Intronic variants in BRCA1 and BRCA2 that affect RNA splicing can be reliably selected by splice-site prediction programs.
The research eventually could lead to better treatments for diseases caused by defects in the body's RNA splicing process.
Intron removal by RNA splicing permits the exons to become contiguous by phosphodiester 5[feet] to 3[feet] linkage.
Nadal-Ginard found the alternative RNA splicing in a muscle protein serendipitously, he says.
We're researching an unexplored area of RNA splicing factors in relation to cancer.
During RNA splicing, most mammalian genes are interrupted by pieces of DNA, called introns, which are selectively removed during the maturation of RNA transcribed from a gene.
Mbnl1 is involved in a process called RNA splicing, in which the messenger RNA copied from a gene gets "edited" before it can direct the synthesis of proteins.
Computational analysis and experimental validation of tumor-associated alternative RNA splicing in human cancer.
7, 2014 /PRNewswire/ -- Today the journal Science published results of a preclinical study demonstrating that treatment with orally available RNA splicing modifiers of the SMN2 gene starting early after birth is preventing deficits in mouse models of Spinal Muscular Atrophy (SMA).
The new molecule boosts the levels of SMN protein in cells by fixing a mistake in a cellular processing mechanism called RNA splicing.
Among the most tedious chapters were a couple of polemics about the importance of biochemistry to the development of molecular biology and whether the discovery of split genes and RNA splicing were revolutionary discoveries or merely important discoveries.
The Human Genome Wide SpliceArray[TM] monitors known and predicted alternative RNA splicing events in close to 21,000 human genes and is used in the Company's biomarker and target discovery process.