RNA splicing


Also found in: Dictionary, Thesaurus, Wikipedia.

splic·ing

(splīs'ing),
1. Attachment of one DNA molecule to another. Synonym(s): gene splicing
2. Removal of introns from mRNA precursors and the reattachment or annealing of exons. Synonym(s): RNA splicing
3. Posttranslational modification of a protein involving two proteolytic enzymes and one ligation; results in the removal of an internal sequence of amino acyl residues.

RNA splicing

(in molecular genetics) the process by which base pairs that interrupt the continuity of genetic information in deoxyribonucleic acid are removed from the precursors of messenger ribonucleic acid.

splic·ing

(splīs'ing)
1. Attachment of one DNA molecule to another.
Synonym(s): gene splicing.
2. Removal of introns from mRNA precursors and the reattachment or annealing of exons.
Synonym(s): RNA splicing.

splic·ing

(splīs'ing)
1. Attachment of one DNA molecule to another.
Synonym(s): gene splicing.
2. Removal of introns from mRNA precursors and the reattachment or annealing of exons.
Synonym(s): RNA splicing.

RNA splicing,

n the process by which base pairs that interrupt the continuity of genetic information in deoxyribonucleic acid are removed from the precursors of messenger ribonucleic acid.
References in periodicals archive ?
Mutations in genes encoding for certain RNA splicing factors that form spliceosome are among the most common mutations found in patients with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and chronic lymphocytic leukemia (CLL), and occur in subsets of patients with solid tumors.
Overall, these researches provide evidence that splice sites are species dependent and the nucleotides that make up the boundary of the splice sites play an important role in RNA splicing.
Intronic variants in BRCA1 and BRCA2 that affect RNA splicing can be reliably selected by splice-site prediction programs.
Messenger RNA splicing is a relatively slow process; modern splicing occurs at a rate of 0.
The research eventually could lead to better treatments for diseases caused by defects in the body's RNA splicing process.
Intron removal by RNA splicing permits the exons to become contiguous by phosphodiester 5[feet] to 3[feet] linkage.
Nadal-Ginard found the alternative RNA splicing in a muscle protein serendipitously, he says.
RNA splicing, a cellular process occurring in every cell, 'edits' RNA to produce functional proteins.
The SMN2 splicing modifiers described in the Science article penetrated into all mouse tissues tested, including brain, spinal cord and muscle, and thus improved SMN2 RNA splicing to increase SMN protein production in these disease-relevant tissues.
Potential RNA splicing signals in AMDV were present on the GFADV genome (online Technical Appendix Figure 1, www.
Their further investigation discovered that a protein known as hnRNP L functions as an RNA splicing factor by promoting the expression of caspase-9b through a process known as RNA splicing.
Chapel Hill, NC), announced the companies have initiated a multi-year collaboration to discover antisense drugs that regulate alternative RNA splicing.