RNA processing

RNA processing

processes involved in the formation of mature, fully functional RNA species from primary RNA transcripts. For eukaryotic mRNA this may involve the removal of INTRONS (RNA splicing) and the addition of a cap at the 5′-end (See CAPPING (1)) and of a Poly(A) tail (see POLYADENYLATION). Generally little modification is made to prokaryotic mRNA; rRNA and tRNA in PROKARYOTES and EUKARYOTES are both modified. Both are cut out of large primary transcripts. For tRNA some of the bases are modified chemically. These processes occurring after TRANSCRIPTION are also called POSTTRANSCRIPTIONAL MODIFICATIONS.
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Our preliminary data reveals that a potent structure in gene expression, The mrna cap, Which co-ordinates rna processing and translation initiation, Is crucial for the development and activation of cd8 t cells.
TDRD4/ring finger protein 17 (RNF17) and TDRD5 are mainly expressed in chromatoid bodies and involved in RNA processing for spermatogenesis (Smith et al.
Their topics include: to the cell and beyond, the realm of molecular genetics, nucleic acids, principles and applications of recombinant DNA, the physical structure of the genomic material, transcription in eukaryotes, the regulation of transcription in bacteria, RNA processing, the players and process of translation, protein processing and modification, DNA replication in bacteria and eukaryotes, and DNA repair.
The team defined the meaning of "words" in RNA, allowing identification of patterns in RNA molecules that proteins use to control RNA processing and movement, which are often altered in disease.
Reduced RNA processing inhibited the translation of proteins required to maintain the mitochondrial electron transport chain that consumes oxygen during cell respiration to produce energy.
Nuclear biologists describe the dynamic remodeling of the nuclear envelope during the cell cycle, the positioning of genes relative to functional landmarks, the Cajal body and histone locus body, DNA damage response, RNA processing, and nuclear ataxias.
There is growing evidence that abnormalities in RNA processing might play a central role in the degeneration of motorneurons.
This polypeptide, CHAMP (cardiac helicase activated by MEF2 protein), bears striking resemblance to a number of other helicase proteins and appears to play a role in RNA processing and transcriptional control in heart muscle.
Most of these motifs are shared among many loci, suggesting that genomes are assembled like Lego blocks from a repertoire of more basic sequence elements, many of which do not encode proteins but other important functions such as transcription, translation, RNA processing, DNA replication, and chromatin condensation.
Finally, antipolymyositis/Scl (anti-PM Scl) and anti-Th/To (which recognizes certain RNA processing enzymes) anti-bodies are seen in about 2% of scleroderma patients.
The only false-positive case was presumably attributable to contamination during RNA processing.