helicase

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helicase

(hel-ĭ-kāz),
A general term describing enzymes capable of unwinding the DNA double helix beginning at the replication fork.
See also: Werner syndrome.

helicase

An enzyme that breaks the hydrogen bonds between the BASE PAIRS in DNA thus separating the two strands of the double helix in the process of replication. Helicase works in conjunction with single-strand binding proteins that attach to the outer side of each single strand preventing the two from rebonding so that two rows of free-ended bases are left as templates on which new complementary strands can be formed.

helicase

an ENZYME that can unwind a NUCLEIC ACID DUPLEX. It disrupts the hydrogen bonds and requires ATP to function.

helicase

an enzyme involved in DNA replication, responsible for unwinding the double helix.
References in periodicals archive ?
The microprocessor complex also contains a variety of cofactors including the DEAD box (amino acid sequence D-E-A-D asp-glu-ala-asp) RNA helicases p68 (DDX5) and p72 (DDX17), as well as heterogeneous nuclear ribonucleoproteins (hnRNPs) [11,12].
Retinoic acid inducible gene or RIG-I is a cytoplasmic RNA helicase (79).
The RNA helicase DDX3 is a component of P bodies and is required for HCV RNA replication (154).
Hepatitis C virus core protein binds to a dead box RNA helicase.
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter.
The nature of these sensors has remained unknown until recently, when 2 putative RNA helicases, RIG-I and MDA5, were identified as sensors for viral dsRNA generated in the cytoplasm during viral infection (2-4).
The phosphorylated form of p68 RNA helicase is only present in cancer cells and is absent in normal cells.
RX-5902 is an exciting first-in-class p68 RNA helicase inhibitor that has considerable commercial potential," said Rick Soni, President of Rexahn.
In the second quarter of 2012, Rexahn expects to file an Investigational New Drug application for a first-in-human clinical trial for RX-5902, an orally available, first-in-class inhibitor of p68 RNA helicase for the treatment of various solid tumors, in particular melanoma.

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