PRDM2

(redirected from RIZ1)

PRDM2

A gene on chromosome 1p36.21 that encodes a tumour suppressor zinc finger protein of the nuclear histone/protein methyltransferase superfamily, which binds to the retinoblastoma protein, oestrogen receptor and the TPA-responsive element (MTE) of the haeme-oxygenase-1 gene. PRDM2 may:
• Play a role in regulating transcription during neuronal differentiation;
• Activate transcription of the haeme-oxygenase-1 gene;
• Be a specific effector of oestrogen activty.

Molecular pathology
PRDM2 activation may be linked to retinoblastoma.
References in periodicals archive ?
Aberrant methylation of the RIZ1 gene in myelodysplastic syndrome and acute myeloid leukemia.
Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.
Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications.