RIPK3

RIPK3

A gene on chromosome 14q11.2 that encodes a serine/threonine/ tyrosine kinase essential for cellular necroptosis in response to the TNF-alpha family of death-inducing cytokines. RIPK3 interacts with and phosphorylates RIPK1 to form a necrosis-inducing complex, binding to and enhancing the activity of GLUL, GLUD1 and PYGL (metabolic enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation), thereby increasing reactive oxygen species production.
Mentioned in ?
References in periodicals archive ?
Researchers identified FLIP and the silencing of another enzyme, named RIPK3, as playing pivotal roles.
Previous research identified RIPK3 as responsible for orchestrating cell death via programmed necrosis.
While loss of caspase-8 was known to be lethal during embryonic development, in this study investigators showed mice that lacked both caspase-8 and RIPK3 were born at normal rates and appeared developmentally normal early in life.
Investigators went on to show that caspase-8 prevents programmed necrosis by combining with FLIP to form an enzyme complex that disrupts RIPK3 functioning and so prevents death via programmed necrosis.