RIPK1


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Related to RIPK1: necroptosis, PubMed

RIPK1

A gene on chromosome 6p25.2 that encodes a serine/threonine/tyrosine kinase which transduces inflammatory and cell-death signals (necroptosis), triggered in response to the binding of ligands to death receptors, activation of pathogen recognition receptors (PRRs) and DNA damage. Activation of TNFR1 by TNF-alpha family cytokines recruits TRADD and TRAF2 to the receptor; ubiquitination by TRAF2 enhances communication with downstream signal transducers in the mitogen-activated protein kinase (MAPK) and NF-kappaB pathways, activating genes that encode inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappaB activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 form a necroptosis-inducing complex.
References in periodicals archive ?
It is negatively regulated by caspase and is dependent on the kinase activity of RIPK1 and RIPK3.
Nec-1 could inhibit RIPK1 expression, endogenous RIPK1 autophosphorylation, and even the formation of RIPK1-RIPK3 complex [22, 30, 33].
However the mTOR inhibitor rapamycin has no influence on the expression of RIPK1, indicating that RIPK1 might be an upstream signal molecule of PA-induced AKT/mTOR activation.