RIPK2

(redirected from RIP2)
Also found in: Acronyms.

RIPK2

A gene on chromosome 8q21 that encodes a serine/threonine/tyrosine kinase which is intimately involved in modulating innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerise, and recruit RIPK2 through CARD-CARD domains. Once recruited, RIPK2 autophosphorylates and undergoes “Lys-63”-linked polyubiquitination by E3 ubiquitin ligases BIRC2 and BIRC3. The polyubiquitinated protein then recruits MAP3K7/TAK1 to IKBKG/NEMO, induces “Lys-63”-linked polyubiquitination of IKBKG/NEMO and activates IKBKB/IKKB.

In turn, NF-kappaB is released from NF-kappaB inhibitors and translocates to the nucleus, where it activates transcription of myriad genes involved in immune response, growth control or anti-apoptosis. It also plays a role during engagement of the T-cell receptor in promoting BCL10 phosphorylation and subsequent NF-kappaB activation.
Mentioned in ?
References in periodicals archive ?
PMACI increased the expressions of RIP2 and caspase-1; whereas NJJ suppressed the expressions of RIP2 and caspase-1 increased in the activated HMC-1 cells (Fig.
Full IP routing offers greater than 20 million packets per second forwarding while supporting dynamic routing using RIP1, RIP2 and OSPF.
4) RIP2 was announcing a rip table every 30 seconds on the LAN side; this was creating a small overflow at the router Ethernet interface.
The XF2020 chipset provides IP-based Layer 3 routing with RIP and RIP2 support for 10/100Mb desktop and workgroup switches for small-to-medium sized businesses.
5Mbps up to 8Mbps and also provides advanced routing functions, such as NAT, DHCP, RIP1, and RIP2.
Leading-edge IPSec tunneling for TCP/IP and IPX network protocols -- Integrated routing via RIP, RIP2 and OSPF -- Three encryption levels including hardware-accelerated Triple DES -- Unlimited-user client support for Windows 95(TM), Windows 98(TM), Windows NT(TM), MacOS, Intel Linux and Sun Solaris -- RADIUS and SecurID user authentication; and full packet filtering -- CompatiView, a GUI management application for Windows and Macintosh, is included with every IntraPort.
Leading-edge IPSec tunneling for TCP/IP and IPX network protocols -- Integrated routing via RIP, RIP2 and OSPF -- Three encryption levels including hardware-accelerated Triple DES -- Unlimited-user client support for Windows 95(TM), Windows 98(TM), Windows NT(TM), MacOS, Intel Linux and Sun Solaris -- MD5/SHA, RADIUS and SecurID authentication; and full packet filtering -- CompatiView, a GUI management application for Windows and Macintosh, is included with every IntraPort.
Leading-edge IPSec tunneling for TCP/IP -- Extensive management capabilities: RADIUS, LDAP and SecurID authentication with granular access control -- Integrated VPN routing with RIP, RIP2 and OSPF support -- Three encryption levels including Triple DES -- Unlimited-user license for all Compatible Systems IntraPort client software
Leading-edge IPSec tunneling for TCP/IP -- IPSec support for legacy protocols including IPX, AppleTalk and Spanning Tree -- Integrated VPN routing with RIP, RIP2 and OSPF support -- Three encryption levels including Triple DES -- Unlimited-user license for all Compatible Systems IntraPort client software -- Support for Windows(R) 95, 98, NT, Macintosh, Intel Linux and Sun Solaris(R)