RIPK1

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RIPK1

A gene on chromosome 6p25.2 that encodes a serine/threonine/tyrosine kinase which transduces inflammatory and cell-death signals (necroptosis), triggered in response to the binding of ligands to death receptors, activation of pathogen recognition receptors (PRRs) and DNA damage. Activation of TNFR1 by TNF-alpha family cytokines recruits TRADD and TRAF2 to the receptor; ubiquitination by TRAF2 enhances communication with downstream signal transducers in the mitogen-activated protein kinase (MAPK) and NF-kappaB pathways, activating genes that encode inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappaB activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 form a necroptosis-inducing complex.
References in periodicals archive ?
When RIP1 is switched off in the experimental model, NFkB and the signaling that promotes tumor growth also is inhibited.
These include RFC 1490 over Frame Relay transports, TCP/IP Routing with RIP-compatible RIP1, RIP2, or static routing on the LAN and/or WAN, Novell IPX Routing, IEEE Bridging, and SNMP-based Network Management.
Enhanced versions of the IP gateway will also support routing protocols such as OSPF, RIP1 and RIP2.
These include PPP and RFC 1483 over ATM transports, TCP/IP Routing with RIP-compatible RIP1, RIP2, or static routing on the LAN and/or WAN, Novell IPX Routing, IEEE Bridging, and SNMP-based Network Management.
Full IP routing offers greater than 20 million packets per second forwarding while supporting dynamic routing using RIP1, RIP2 and OSPF.
Routing Protocols: The GRF 1600 supports BGP4 (including the latest enhancements: route reflection, MEDS, communities, DPAs, flat route damping, weighted route damping and confederations), OSPF, EGP, BGP3, IS-IS, RIP1, and RIP2.